TY - JOUR
T1 - Insulin infusion reduces hepatocyte growth factor in lean humans
AU - de Courten, Barbora
AU - de Courten, Maximilian
AU - Dougherty, Sonia
AU - Forbes, Josephine M
AU - Potts, Jenna R
AU - Considine, Robert V
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2013/5
Y1 - 2013/5
N2 - OBJECTIVE: Plasma Hepatocyte Growth Factor (HGF) is significantly elevated in obesity and may contribute to vascular disease, metabolic syndrome or cancer in obese individuals. The current studies were done to determine if hyperinsulinemia increases plasma HGF. MATERIALS/METHODS: Twenty-two participants (10 women/12 men, BMI 20.6-34.5 kg/m(2), age 18-49 years) underwent a hyperinsulinemic euglycemic clamp with measurement of HGF at baseline and steady state. Relationships between baseline HGF, anthropometrics, triglycerides, liver enzymes, c-reactive protein and adiponectin were also evaluated. RESULTS: Fasting HGF was positively correlated (P
AB - OBJECTIVE: Plasma Hepatocyte Growth Factor (HGF) is significantly elevated in obesity and may contribute to vascular disease, metabolic syndrome or cancer in obese individuals. The current studies were done to determine if hyperinsulinemia increases plasma HGF. MATERIALS/METHODS: Twenty-two participants (10 women/12 men, BMI 20.6-34.5 kg/m(2), age 18-49 years) underwent a hyperinsulinemic euglycemic clamp with measurement of HGF at baseline and steady state. Relationships between baseline HGF, anthropometrics, triglycerides, liver enzymes, c-reactive protein and adiponectin were also evaluated. RESULTS: Fasting HGF was positively correlated (P
U2 - 10.1016/j.metabol.2012.10.013
DO - 10.1016/j.metabol.2012.10.013
M3 - Journal article
C2 - 23190875
SN - 0026-0495
VL - 62
SP - 647
EP - 650
JO - Metabolism
JF - Metabolism
IS - 5
ER -
