Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

Benjamin Ole Wolthers; Pernille R. Mogensen; Thomas L. Frandsen; Jonas Abrahamsson; Mikael Behrendtz; Mats Heyman; Olli Lohi; Ulrika Norén-Nyström; Ellen Ruud; Kjeld Schmiegelow

doi:10.1002/pbc.27437

Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

Benjamin Ole Wolthers, Pernille R. Mogensen, Thomas L. Frandsen, Jonas Abrahamsson, Mikael Behrendtz, Mats Heyman, Olli Lohi, Ulrika Norén-Nyström, Ellen Ruud, Kjeld Schmiegelow^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

5 Citationer (Scopus)

Abstract

Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

Originalsprog	Engelsk
Artikelnummer	e27437
Bogserie	Pediatric Blood and Cancer
Vol/bind	66
Udgave nummer	1
Antal sider	4
ISSN	1545-5009
DOI	https://doi.org/10.1002/pbc.27437
Status	Udgivet - 2019

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10.1002/pbc.27437

Citationsformater

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title = "Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia",

abstract = "Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.",

keywords = "acute lymphoblastic leukemia, diabetes, pancreatitis, toxicity",

author = "Wolthers, {Benjamin Ole} and Mogensen, {Pernille R.} and Frandsen, {Thomas L.} and Jonas Abrahamsson and Mikael Behrendtz and Mats Heyman and Olli Lohi and Ulrika Nor{\'e}n-Nystr{\"o}m and Ellen Ruud and Kjeld Schmiegelow",

year = "2019",

doi = "10.1002/pbc.27437",

language = "English",

volume = "66",

journal = "Medical and Pediatric Oncology. Supplement",

issn = "0740-8226",

publisher = "JohnWiley & Sons, Inc.",

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TY - JOUR

T1 - Insulin-dependent diabetes

T2 - A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

AU - Wolthers, Benjamin Ole

AU - Mogensen, Pernille R.

AU - Frandsen, Thomas L.

AU - Abrahamsson, Jonas

AU - Behrendtz, Mikael

AU - Heyman, Mats

AU - Lohi, Olli

AU - Norén-Nyström, Ulrika

AU - Ruud, Ellen

AU - Schmiegelow, Kjeld

PY - 2019

Y1 - 2019

N2 - Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

AB - Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

KW - acute lymphoblastic leukemia

KW - diabetes

KW - pancreatitis

KW - toxicity

U2 - 10.1002/pbc.27437

DO - 10.1002/pbc.27437

M3 - Journal article

C2 - 30216644

AN - SCOPUS:85053481525

SN - 0740-8226

VL - 66

JO - Medical and Pediatric Oncology. Supplement

JF - Medical and Pediatric Oncology. Supplement

IS - 1

M1 - e27437

ER -

Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

Abstract

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