Innovative Methods and Applications in Mucoadhesion Research

Alan R Mackie; Francisco M Goycoolea; Bianca Menchicchi; Carla Marcella Caramella; Francesca Saporito; Seunghwan Lee; Karen Stephansen; Ioannis S Chronakis; Marianne Hiorth; Malgorzata Adamczak; Max Waldner; Hanne Mørck Nielsen; Luciano Marcelloni

doi:10.1002/mabi.201600534

Innovative Methods and Applications in Mucoadhesion Research

Alan R Mackie, Francisco M Goycoolea, Bianca Menchicchi, Carla Marcella Caramella, Francesca Saporito, Seunghwan Lee, Karen Stephansen, Ioannis S Chronakis, Marianne Hiorth, Malgorzata Adamczak, Max Waldner, Hanne Mørck Nielsen, Luciano Marcelloni

39 Citationer (Scopus)

Abstract

The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2–3 September 2015 as a satellite event of the ICCC 13th—EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described. (Figure presented.).

Originalsprog	Engelsk
Artikelnummer	1600534
Tidsskrift	Macromolecular Bioscience
Vol/bind	17
Udgave nummer	8
Antal sider	32
ISSN	1616-5187
DOI	https://doi.org/10.1002/mabi.201600534
Status	Udgivet - aug. 2017

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10.1002/mabi.201600534

Citationsformater

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abstract = "The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2–3 September 2015 as a satellite event of the ICCC 13th—EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described. (Figure presented.).",

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AU - Goycoolea, Francisco M

AU - Menchicchi, Bianca

AU - Caramella, Carla Marcella

AU - Saporito, Francesca

AU - Lee, Seunghwan

AU - Stephansen, Karen

AU - Chronakis, Ioannis S

AU - Hiorth, Marianne

AU - Adamczak, Malgorzata

AU - Waldner, Max

AU - Nielsen, Hanne Mørck

AU - Marcelloni, Luciano

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AB - The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2–3 September 2015 as a satellite event of the ICCC 13th—EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described. (Figure presented.).

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JO - Macromolecular Bioscience

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ER -

Innovative Methods and Applications in Mucoadhesion Research

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