Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study

Lena Kirchner Brahe; Lars Angquist; Lesli Hingstrup Larsen; Karani S Vimaleswaran; Jörg Hager; Nathalie Viguerie; Ruth J F Loos; Teodora Handjieva-Darlenska; Susan A Jebb; Petr Hlavaty; Thomas Meinert Larsen; J Alfredo Martinez; Angeliki Papadaki; Andreas F H Pfeiffer; Marleen A van Baak; Thorkild I A Sørensen; Claus Holst; Dominique Langin; Arne Astrup; Wim H M Saris

doi:10.1017/S0007114512006058

Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study

Lena Kirchner Brahe, Lars Angquist, Lesli Hingstrup Larsen, Karani S Vimaleswaran, Jörg Hager, Nathalie Viguerie, Ruth J F Loos, Teodora Handjieva-Darlenska, Susan A Jebb, Petr Hlavaty, Thomas Meinert Larsen, J Alfredo Martinez, Angeliki Papadaki, Andreas F H Pfeiffer, Marleen A van Baak, Thorkild I A Sørensen, Claus Holst, Dominique Langin, Arne Astrup, Wim H M Saris

10 Citationer (Scopus)

Abstract

Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

Originalsprog	Engelsk
Tidsskrift	British Journal of Nutrition
Vol/bind	110
Udgave nummer	5
Sider (fra-til)	790-796
Antal sider	7
ISSN	0007-1145
DOI	https://doi.org/10.1017/S0007114512006058
Status	Udgivet - 14 sep. 2013

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10.1017/S0007114512006058

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Brahe, L. K., Angquist, L., Larsen, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, R. J. F., Handjieva-Darlenska, T., Jebb, S. A., Hlavaty, P., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, T. I. A., Holst, C., Langin, D., Astrup, A., & Saris, W. H. M. (2013). Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. British Journal of Nutrition, 110(5), 790-796. https://doi.org/10.1017/S0007114512006058

Brahe, LK, Angquist, L, Larsen, LH, Vimaleswaran, KS, Hager, J, Viguerie, N, Loos, RJF, Handjieva-Darlenska, T, Jebb, SA, Hlavaty, P, Larsen, TM, Martinez, JA, Papadaki, A, Pfeiffer, AFH, van Baak, MA, Sørensen, TIA, Holst, C, Langin, D, Astrup, A & Saris, WHM 2013, 'Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study', British Journal of Nutrition, bind 110, nr. 5, s. 790-796. https://doi.org/10.1017/S0007114512006058

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title = "Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study",

abstract = "Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.",

author = "Brahe, {Lena Kirchner} and Lars Angquist and Larsen, {Lesli Hingstrup} and Vimaleswaran, {Karani S} and J{\"o}rg Hager and Nathalie Viguerie and Loos, {Ruth J F} and Teodora Handjieva-Darlenska and Jebb, {Susan A} and Petr Hlavaty and Larsen, {Thomas Meinert} and Martinez, {J Alfredo} and Angeliki Papadaki and Pfeiffer, {Andreas F H} and {van Baak}, {Marleen A} and S{\o}rensen, {Thorkild I A} and Claus Holst and Dominique Langin and Arne Astrup and Saris, {Wim H M}",

note = "CURIS 2013 NEXS 083",

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doi = "10.1017/S0007114512006058",

language = "English",

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pages = "790--796",

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T1 - Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids

T2 - the DiOGenes study

AU - Brahe, Lena Kirchner

AU - Angquist, Lars

AU - Larsen, Lesli Hingstrup

AU - Vimaleswaran, Karani S

AU - Hager, Jörg

AU - Viguerie, Nathalie

AU - Loos, Ruth J F

AU - Handjieva-Darlenska, Teodora

AU - Jebb, Susan A

AU - Hlavaty, Petr

AU - Larsen, Thomas Meinert

AU - Martinez, J Alfredo

AU - Papadaki, Angeliki

AU - Pfeiffer, Andreas F H

AU - van Baak, Marleen A

AU - Sørensen, Thorkild I A

AU - Holst, Claus

AU - Langin, Dominique

AU - Astrup, Arne

AU - Saris, Wim H M

N1 - CURIS 2013 NEXS 083

PY - 2013/9/14

Y1 - 2013/9/14

N2 - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

AB - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

U2 - 10.1017/S0007114512006058

DO - 10.1017/S0007114512006058

M3 - Journal article

C2 - 23360819

SN - 0007-1145

VL - 110

SP - 790

EP - 796

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 5

ER -

Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study

Abstract

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