Inflammation, immunity, and vaccines for Helicobacter pylori

TY - JOUR

T1 - Inflammation, immunity, and vaccines for Helicobacter pylori

AU - D'Elios, Mario M

AU - Andersen, Leif P

N1 - Keywords: Animals; Asthma; Bacterial Vaccines; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Immunity

PY - 2009

Y1 - 2009

N2 - Helicobacter pylori infects almost half of the population worldwide and represents the major cause of gastroduodenal diseases, such as duodenal and gastric ulcer, gastric adenocarcinoma, autoimmune gastritis, and B-cell lymphoma of mucosa-associated lymphoid tissue. Helicobacter pylori induces the activation of a complex and fascinating cytokine and chemokine network in the gastric mucosa. Different bacterial and environmental factors, other concomitant infections, and host genetics may influence the balance between mucosal tolerance and inflammation in the course of H. pylori infection. An inverse association between H. pylori prevalence and the frequencies of asthma and allergies was demonstrated, and the neutrophil activating protein of H. pylori was shown to inhibit the allergic inflammation of bronchial asthma. During the last year, significant progress was made on the road to the first efficient vaccine for H. pylori that will represent a novel and very important bullet against both infection and gastric cancer.

AB - Helicobacter pylori infects almost half of the population worldwide and represents the major cause of gastroduodenal diseases, such as duodenal and gastric ulcer, gastric adenocarcinoma, autoimmune gastritis, and B-cell lymphoma of mucosa-associated lymphoid tissue. Helicobacter pylori induces the activation of a complex and fascinating cytokine and chemokine network in the gastric mucosa. Different bacterial and environmental factors, other concomitant infections, and host genetics may influence the balance between mucosal tolerance and inflammation in the course of H. pylori infection. An inverse association between H. pylori prevalence and the frequencies of asthma and allergies was demonstrated, and the neutrophil activating protein of H. pylori was shown to inhibit the allergic inflammation of bronchial asthma. During the last year, significant progress was made on the road to the first efficient vaccine for H. pylori that will represent a novel and very important bullet against both infection and gastric cancer.

U2 - 10.1111/j.1523-5378.2009.00698.x

DO - 10.1111/j.1523-5378.2009.00698.x

M3 - Journal article

C2 - 19712164

SN - 1083-4389

VL - 14 Suppl 1

SP - 21

EP - 28

JO - Helicobacter

JF - Helicobacter

ER -