Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006

Anja Pinborg; Anne Loft; Anna-Karina Aaris Henningsen; Steen Rasmussen; Anders Nyboe Andersen

doi:10.1016/j.fertnstert.2009.05.091

Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006

Anja Pinborg, Anne Loft, Anna-Karina Aaris Henningsen, Steen Rasmussen, Anders Nyboe Andersen

199 Citationer (Scopus)

Abstract

Objective: To examine infant outcome of singletons born after cryopreservation of embryos (Cryo). Design: National population-based controlled follow-up study. Setting: Denmark, 1995-2007. Patient(s): The study population was 957 Cryo singletons (Cryo-IVF, n = 660; Cryo-ICSI, n = 244; Cryo-IVF/-ICSI, n = 53). The first control group was all singletons born after fresh IVF or intracytoplasmic sperm injection (ICSI) during the same period (IVF, n = 6904; ICSI, n = 3425). The second control group comprised a random sample of non-assisted reproductive technology (ART) singletons (n = 4800). Intervention(s): All observations were obtained from national registers. Main Outcome Measure(s): Low birth weight (LBW; <2500 g), preterm birth (PTB; < 37 weeks), congenital malformations, mortality, and morbidity. Result(s): Birth weight was higher in Cryo (mean = 3578 g, SD = 625) versus fresh (mean = 3373 g, SD = 648) and in Cryo versus non-ART (mean = 3537 g, SD = 572), and this was also the case for first birth only. Lower adjusted risk of LBW (odds ratio [OR] = 0.63; 95% confidence interval [CI], 0.45-0.87) and PTB (OR = 0.70; 95% CI, 0.53-0.92) was observed in Cryo versus fresh. Similar LBW and PTB rates were observed when comparing Cryo with non-ART, but the perinatal mortality rate was doubled in Cryo (1.6%) compared with non-ART (0.8%) singletons, and the adjusted risks of very preterm birth (<34 weeks) and neonatal admittance were also significantly increased. No significant differences in the prevalence rates of birth defects, neurological sequelae, malignancies, and imprinting-related diseases were observed between the Cryo and the two control groups. However higher malformation and cerebral palsy rates were observed in the total Fresh vs. non-ART group. Conclusion(s): Cryo singletons have better neonatal outcome than offspring after fresh ET but poorer compared with non-ART singletons.

Originalsprog	Engelsk
Tidsskrift	Fertility and Sterility
Vol/bind	94
Udgave nummer	4
Sider (fra-til)	1320-7
Antal sider	8
ISSN	0015-0282
DOI	https://doi.org/10.1016/j.fertnstert.2009.05.091
Status	Udgivet - 1 sep. 2010

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10.1016/j.fertnstert.2009.05.091

http://www.fertstert.org/article/S0015028209012977/pdf

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title = "Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006",

abstract = "Objective: To examine infant outcome of singletons born after cryopreservation of embryos (Cryo). Design: National population-based controlled follow-up study. Setting: Denmark, 1995-2007. Patient(s): The study population was 957 Cryo singletons (Cryo-IVF, n = 660; Cryo-ICSI, n = 244; Cryo-IVF/-ICSI, n = 53). The first control group was all singletons born after fresh IVF or intracytoplasmic sperm injection (ICSI) during the same period (IVF, n = 6904; ICSI, n = 3425). The second control group comprised a random sample of non-assisted reproductive technology (ART) singletons (n = 4800). Intervention(s): All observations were obtained from national registers. Main Outcome Measure(s): Low birth weight (LBW; <2500 g), preterm birth (PTB; < 37 weeks), congenital malformations, mortality, and morbidity. Result(s): Birth weight was higher in Cryo (mean = 3578 g, SD = 625) versus fresh (mean = 3373 g, SD = 648) and in Cryo versus non-ART (mean = 3537 g, SD = 572), and this was also the case for first birth only. Lower adjusted risk of LBW (odds ratio [OR] = 0.63; 95% confidence interval [CI], 0.45-0.87) and PTB (OR = 0.70; 95% CI, 0.53-0.92) was observed in Cryo versus fresh. Similar LBW and PTB rates were observed when comparing Cryo with non-ART, but the perinatal mortality rate was doubled in Cryo (1.6%) compared with non-ART (0.8%) singletons, and the adjusted risks of very preterm birth (<34 weeks) and neonatal admittance were also significantly increased. No significant differences in the prevalence rates of birth defects, neurological sequelae, malignancies, and imprinting-related diseases were observed between the Cryo and the two control groups. However higher malformation and cerebral palsy rates were observed in the total Fresh vs. non-ART group. Conclusion(s): Cryo singletons have better neonatal outcome than offspring after fresh ET but poorer compared with non-ART singletons.",

author = "Anja Pinborg and Anne Loft and {Aaris Henningsen}, Anna-Karina and Steen Rasmussen and Andersen, {Anders Nyboe}",

year = "2010",

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doi = "10.1016/j.fertnstert.2009.05.091",

language = "English",

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T1 - Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006

AU - Pinborg, Anja

AU - Loft, Anne

AU - Aaris Henningsen, Anna-Karina

AU - Rasmussen, Steen

AU - Andersen, Anders Nyboe

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Objective: To examine infant outcome of singletons born after cryopreservation of embryos (Cryo). Design: National population-based controlled follow-up study. Setting: Denmark, 1995-2007. Patient(s): The study population was 957 Cryo singletons (Cryo-IVF, n = 660; Cryo-ICSI, n = 244; Cryo-IVF/-ICSI, n = 53). The first control group was all singletons born after fresh IVF or intracytoplasmic sperm injection (ICSI) during the same period (IVF, n = 6904; ICSI, n = 3425). The second control group comprised a random sample of non-assisted reproductive technology (ART) singletons (n = 4800). Intervention(s): All observations were obtained from national registers. Main Outcome Measure(s): Low birth weight (LBW; <2500 g), preterm birth (PTB; < 37 weeks), congenital malformations, mortality, and morbidity. Result(s): Birth weight was higher in Cryo (mean = 3578 g, SD = 625) versus fresh (mean = 3373 g, SD = 648) and in Cryo versus non-ART (mean = 3537 g, SD = 572), and this was also the case for first birth only. Lower adjusted risk of LBW (odds ratio [OR] = 0.63; 95% confidence interval [CI], 0.45-0.87) and PTB (OR = 0.70; 95% CI, 0.53-0.92) was observed in Cryo versus fresh. Similar LBW and PTB rates were observed when comparing Cryo with non-ART, but the perinatal mortality rate was doubled in Cryo (1.6%) compared with non-ART (0.8%) singletons, and the adjusted risks of very preterm birth (<34 weeks) and neonatal admittance were also significantly increased. No significant differences in the prevalence rates of birth defects, neurological sequelae, malignancies, and imprinting-related diseases were observed between the Cryo and the two control groups. However higher malformation and cerebral palsy rates were observed in the total Fresh vs. non-ART group. Conclusion(s): Cryo singletons have better neonatal outcome than offspring after fresh ET but poorer compared with non-ART singletons.

AB - Objective: To examine infant outcome of singletons born after cryopreservation of embryos (Cryo). Design: National population-based controlled follow-up study. Setting: Denmark, 1995-2007. Patient(s): The study population was 957 Cryo singletons (Cryo-IVF, n = 660; Cryo-ICSI, n = 244; Cryo-IVF/-ICSI, n = 53). The first control group was all singletons born after fresh IVF or intracytoplasmic sperm injection (ICSI) during the same period (IVF, n = 6904; ICSI, n = 3425). The second control group comprised a random sample of non-assisted reproductive technology (ART) singletons (n = 4800). Intervention(s): All observations were obtained from national registers. Main Outcome Measure(s): Low birth weight (LBW; <2500 g), preterm birth (PTB; < 37 weeks), congenital malformations, mortality, and morbidity. Result(s): Birth weight was higher in Cryo (mean = 3578 g, SD = 625) versus fresh (mean = 3373 g, SD = 648) and in Cryo versus non-ART (mean = 3537 g, SD = 572), and this was also the case for first birth only. Lower adjusted risk of LBW (odds ratio [OR] = 0.63; 95% confidence interval [CI], 0.45-0.87) and PTB (OR = 0.70; 95% CI, 0.53-0.92) was observed in Cryo versus fresh. Similar LBW and PTB rates were observed when comparing Cryo with non-ART, but the perinatal mortality rate was doubled in Cryo (1.6%) compared with non-ART (0.8%) singletons, and the adjusted risks of very preterm birth (<34 weeks) and neonatal admittance were also significantly increased. No significant differences in the prevalence rates of birth defects, neurological sequelae, malignancies, and imprinting-related diseases were observed between the Cryo and the two control groups. However higher malformation and cerebral palsy rates were observed in the total Fresh vs. non-ART group. Conclusion(s): Cryo singletons have better neonatal outcome than offspring after fresh ET but poorer compared with non-ART singletons.

U2 - 10.1016/j.fertnstert.2009.05.091

DO - 10.1016/j.fertnstert.2009.05.091

M3 - Journal article

SN - 1546-2501

VL - 94

SP - 1320

EP - 1327

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

IS - 4

ER -

Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006

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