Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

D B Pedersen; T Eysteinsson; E Stefánsson; Jens Folke Kiilgaard; M La Cour; K Bang; P K Jensen

doi:http://dx.doi.org/10.1136/bjo.2003.041251

Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

D B Pedersen, T Eysteinsson, E Stefánsson, Jens Folke Kiilgaard, M La Cour, K Bang, P K Jensen

9 Citationer (Scopus)

Abstract

Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.

Originalsprog	Engelsk
Tidsskrift	British Journal of Ophthalmology
Vol/bind	88
Udgave nummer	8
Sider (fra-til)	1088-91
Antal sider	4
ISSN	0007-1161
DOI	https://doi.org/10.1136/bjo.2003.041251
Status	Udgivet - 2004

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http://dx.doi.org/10.1136/bjo.2003.041251

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abstract = "Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.",

author = "Pedersen, {D B} and T Eysteinsson and E Stef{\'a}nsson and Kiilgaard, {Jens Folke} and {La Cour}, M and K Bang and Jensen, {P K}",

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TY - JOUR

T1 - Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

AU - Pedersen, D B

AU - Eysteinsson, T

AU - Stefánsson, E

AU - Kiilgaard, Jens Folke

AU - La Cour, M

AU - Bang, K

AU - Jensen, P K

PY - 2004

Y1 - 2004

N2 - Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.

AB - Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.

U2 - http://dx.doi.org/10.1136/bjo.2003.041251

DO - http://dx.doi.org/10.1136/bjo.2003.041251

M3 - Journal article

SN - 0007-1161

VL - 88

SP - 1088

EP - 1091

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 8

ER -

Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

Abstract

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