Indoleamine 2,3-dioxygenase vaccination

TY - JOUR

T1 - Indoleamine 2,3-dioxygenase vaccination

AU - Andersen, Mads Hald

AU - Svane, Inge Marie

PY - 2015/1/2

Y1 - 2015/1/2

N2 - Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer. Further, a recent phase I clinical trial demonstrated long-lasting disease stabilization without toxicity in patients with non-small-cell lung cancer (NSCLC) who were vaccinated with an IDO-derived HLA-A2-restricted epitope.

AB - Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer. Further, a recent phase I clinical trial demonstrated long-lasting disease stabilization without toxicity in patients with non-small-cell lung cancer (NSCLC) who were vaccinated with an IDO-derived HLA-A2-restricted epitope.

U2 - 10.4161/2162402x.2014.983770

DO - 10.4161/2162402x.2014.983770

M3 - Journal article

C2 - 25949864

SN - 2162-4011

VL - 4

SP - 1

EP - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 1

M1 - e983770

ER -