Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping

Kit Melissa Larsen; Morten Mørup; Michelle Rosgaard Birknow; Elvira Fischer; Line Olsen; Michael Didriksen; William Frans Christiaan Baaré; Thomas Mears Werge; Marta Isabel Garrido; Hartwig Roman Siebner

doi:10.1016/j.nicl.2019.101721

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping

Kit Melissa Larsen^*, Morten Mørup, Michelle Rosgaard Birknow, Elvira Fischer, Line Olsen, Michael Didriksen, William Frans Christiaan Baaré, Thomas Mears Werge, Marta Isabel Garrido, Hartwig Roman Siebner

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

2 Citationer (Scopus)

6 Downloads (Pure)

Abstract

One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12–25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Using posterior probability maps and dynamic causal modelling we tested three different models accounting for repetition dependent changes in cortical responses as well as in effective connectivity; namely an adaptation model, a prediction model, and a model including both adaptation and prediction. Repetition-dependent changes were parametrically modulated by a combination of adaptation and prediction and were apparent in both cortical responses and in the underlying effective connectivity. This effect was reduced in individuals with a 22q11.2 deletion and was negatively correlated with negative symptom severity. Follow-up analysis showed that the reduced effect of the combined adaptation and prediction model seen in individuals with 22q11.2 deletion was driven by reduced adaptation rather than prediction failure. Our findings suggest that adaptation is reduced in individuals with a 22q11.2 deletion, which can be interpreted in light of the framework of predictive coding as a failure to suppress prediction errors.

Originalsprog	Engelsk
Artikelnummer	101721
Tidsskrift	NeuroImage: Clinical
Vol/bind	22
ISSN	2213-1582
DOI	https://doi.org/10.1016/j.nicl.2019.101721
Status	Udgivet - 2019

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10.1016/j.nicl.2019.101721Licens: CC BY-NC-ND

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mappingForlagets udgivne version, 1,69 MBLicens: CC BY-NC-ND

Citationsformater

Larsen, K. M., Mørup, M., Birknow, M. R., Fischer, E., Olsen, L., Didriksen, M., Baaré, W. F. C., Werge, T. M., Garrido, M. I., & Siebner, H. R. (2019). Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping. NeuroImage: Clinical, 22, [101721]. https://doi.org/10.1016/j.nicl.2019.101721

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title = "Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping",

abstract = "One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12–25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Using posterior probability maps and dynamic causal modelling we tested three different models accounting for repetition dependent changes in cortical responses as well as in effective connectivity; namely an adaptation model, a prediction model, and a model including both adaptation and prediction. Repetition-dependent changes were parametrically modulated by a combination of adaptation and prediction and were apparent in both cortical responses and in the underlying effective connectivity. This effect was reduced in individuals with a 22q11.2 deletion and was negatively correlated with negative symptom severity. Follow-up analysis showed that the reduced effect of the combined adaptation and prediction model seen in individuals with 22q11.2 deletion was driven by reduced adaptation rather than prediction failure. Our findings suggest that adaptation is reduced in individuals with a 22q11.2 deletion, which can be interpreted in light of the framework of predictive coding as a failure to suppress prediction errors.",

keywords = "22q11 deletion syndrome, Dynamic causal modelling, EEG, Mismatch negativity, Posterior probability maps, Repetition suppression",

author = "Larsen, {Kit Melissa} and Morten M{\o}rup and Birknow, {Michelle Rosgaard} and Elvira Fischer and Line Olsen and Michael Didriksen and Baar{\'e}, {William Frans Christiaan} and Werge, {Thomas Mears} and Garrido, {Marta Isabel} and Siebner, {Hartwig Roman}",

year = "2019",

doi = "10.1016/j.nicl.2019.101721",

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volume = "22",

journal = "NeuroImage: Clinical",

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T1 - Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds

T2 - Evidence from Bayesian mapping

AU - Larsen, Kit Melissa

AU - Mørup, Morten

AU - Birknow, Michelle Rosgaard

AU - Fischer, Elvira

AU - Olsen, Line

AU - Didriksen, Michael

AU - Baaré, William Frans Christiaan

AU - Werge, Thomas Mears

AU - Garrido, Marta Isabel

AU - Siebner, Hartwig Roman

PY - 2019

Y1 - 2019

N2 - One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12–25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Using posterior probability maps and dynamic causal modelling we tested three different models accounting for repetition dependent changes in cortical responses as well as in effective connectivity; namely an adaptation model, a prediction model, and a model including both adaptation and prediction. Repetition-dependent changes were parametrically modulated by a combination of adaptation and prediction and were apparent in both cortical responses and in the underlying effective connectivity. This effect was reduced in individuals with a 22q11.2 deletion and was negatively correlated with negative symptom severity. Follow-up analysis showed that the reduced effect of the combined adaptation and prediction model seen in individuals with 22q11.2 deletion was driven by reduced adaptation rather than prediction failure. Our findings suggest that adaptation is reduced in individuals with a 22q11.2 deletion, which can be interpreted in light of the framework of predictive coding as a failure to suppress prediction errors.

AB - One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12–25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Using posterior probability maps and dynamic causal modelling we tested three different models accounting for repetition dependent changes in cortical responses as well as in effective connectivity; namely an adaptation model, a prediction model, and a model including both adaptation and prediction. Repetition-dependent changes were parametrically modulated by a combination of adaptation and prediction and were apparent in both cortical responses and in the underlying effective connectivity. This effect was reduced in individuals with a 22q11.2 deletion and was negatively correlated with negative symptom severity. Follow-up analysis showed that the reduced effect of the combined adaptation and prediction model seen in individuals with 22q11.2 deletion was driven by reduced adaptation rather than prediction failure. Our findings suggest that adaptation is reduced in individuals with a 22q11.2 deletion, which can be interpreted in light of the framework of predictive coding as a failure to suppress prediction errors.

KW - 22q11 deletion syndrome

KW - Dynamic causal modelling

KW - EEG

KW - Mismatch negativity

KW - Posterior probability maps

KW - Repetition suppression

U2 - 10.1016/j.nicl.2019.101721

DO - 10.1016/j.nicl.2019.101721

M3 - Journal article

C2 - 30785050

AN - SCOPUS:85061628686

SN - 2213-1582

VL - 22

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

M1 - 101721

ER -

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping

Abstract

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