Individualized Therapy Is a Long-Term Cost-Effective Method Compared to Dose Intensification in Crohn's Disease Patients Failing Infliximab

TY - JOUR

T1 - Individualized Therapy Is a Long-Term Cost-Effective Method Compared to Dose Intensification in Crohn's Disease Patients Failing Infliximab

AU - Steenholdt, Casper

AU - Brynskov, Jørn

AU - Thomsen, Ole Ø

AU - Munck, Lars K

AU - Fallingborg, Jan

AU - Christensen, Lisbet A

AU - Pedersen, Gitte

AU - Kjeldsen, Jens

AU - Jacobsen, Bent A

AU - Oxholm, Anne Sophie

AU - Kjellberg, Jakob

AU - Bendtzen, Klaus

AU - Ainsworth, Mark A

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Background: In Crohn’s disease patients failing infliximab therapy, interventions defined by an algorithm based on infliximab and anti-infliximab antibody measurements have proven more cost-effective than intensifying the infliximab regimen. Aim: This study investigated long-term economic outcomes at the week 20 follow-up study visit and after 1 year. Clinical outcomes were assessed at week 20. Methods: Follow-up from a 12-week, single-blind, clinical trial where patients with infliximab treatment failure were randomized to infliximab intensification (5 mg/kg every 4 weeks) (n = 36), or algorithm-defined interventions (n = 33). Accumulated costs, expressed as mean costs per patient, were based on the Danish National Patient Registry. Results: At the scheduled week 20 follow-up study visit, response and remission rates were similar in all study subpopulations between patients treated by the algorithm or by infliximab intensification. However, the sum of healthcare costs related to Crohn’s disease was substantially lower (31 %) for patients randomized to algorithm-based interventions than infliximab intensification in the intention-to-treat population: $11,940 versus $17,236; p = 0.005. For per-protocol patients (n = 55), costs at the week 20 follow-up visit were even lower (49 %) in the algorithm group: $8,742 versus $17,236; p = 0.002. Figures were similar for patients having completed the 12-week trial as per protocol (50 % reduction in costs) (n = 45). Among patients continuing the allocated study intervention throughout the entire 20-week follow-up period (n = 29), costs were reduced by 60 % in algorithm-treated patients: $7,056 versus $17,776; p < 0.001. Cost-reduction percentages remained stable throughout one year. Conclusion: Economic benefit of algorithm-based interventions at infliximab failure is maintained throughout 1 year.

AB - Background: In Crohn’s disease patients failing infliximab therapy, interventions defined by an algorithm based on infliximab and anti-infliximab antibody measurements have proven more cost-effective than intensifying the infliximab regimen. Aim: This study investigated long-term economic outcomes at the week 20 follow-up study visit and after 1 year. Clinical outcomes were assessed at week 20. Methods: Follow-up from a 12-week, single-blind, clinical trial where patients with infliximab treatment failure were randomized to infliximab intensification (5 mg/kg every 4 weeks) (n = 36), or algorithm-defined interventions (n = 33). Accumulated costs, expressed as mean costs per patient, were based on the Danish National Patient Registry. Results: At the scheduled week 20 follow-up study visit, response and remission rates were similar in all study subpopulations between patients treated by the algorithm or by infliximab intensification. However, the sum of healthcare costs related to Crohn’s disease was substantially lower (31 %) for patients randomized to algorithm-based interventions than infliximab intensification in the intention-to-treat population: $11,940 versus $17,236; p = 0.005. For per-protocol patients (n = 55), costs at the week 20 follow-up visit were even lower (49 %) in the algorithm group: $8,742 versus $17,236; p = 0.002. Figures were similar for patients having completed the 12-week trial as per protocol (50 % reduction in costs) (n = 45). Among patients continuing the allocated study intervention throughout the entire 20-week follow-up period (n = 29), costs were reduced by 60 % in algorithm-treated patients: $7,056 versus $17,776; p < 0.001. Cost-reduction percentages remained stable throughout one year. Conclusion: Economic benefit of algorithm-based interventions at infliximab failure is maintained throughout 1 year.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Algorithms

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Antibodies, Monoclonal

KW - Cost-Benefit Analysis

KW - Crohn Disease

KW - Female

KW - Follow-Up Studies

KW - Health Care Costs

KW - Humans

KW - Infliximab

KW - Intention to Treat Analysis

KW - Male

KW - Middle Aged

KW - Precision Medicine

KW - Single-Blind Method

KW - Time Factors

KW - Treatment Failure

KW - Young Adult

U2 - 10.1007/s10620-015-3581-4

DO - 10.1007/s10620-015-3581-4

M3 - Journal article

C2 - 25673037

SN - 0163-2116

VL - 60

SP - 2762

EP - 2770

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 9

ER -