Individual testosterone decline and future mortality risk in men

TY - JOUR

T1 - Individual testosterone decline and future mortality risk in men

AU - Holmboe, Stine Agergaard

AU - Skakkebaek, Niels E.

AU - Juul, Anders

AU - Scheike, Thomas

AU - Jensen, Tina Kold

AU - Linneberg, Allan

AU - Thuesen, Betina H.

AU - Andersson, Anna-Maria

PY - 2018/1

Y1 - 2018/1

N2 - Objective: Male aging is characterized by a decline in testosterone (TS) levels with a substantial variability between subjects. However, it is unclear whether differences in age-related changes in TS are associated with general health. We investigated associations between mortality and intra-individual changes in serum levels of total TS, SHBG, free TS and LH during a ten-year period with up to 18 years of registry follow-up. Design: 1167 men aged 30-60 years participating in the Danish Monitoring Trends and Determinants of Cardiovascular Disease (MONICA1) study and who had a follow-up examination ten years later (MONICA10) were included. From MONICA10, the men were followed up to 18 years (mean: 15.2 years) based on the information from national mortality registries via their unique personal ID numbers. Methods: Cox proportional hazard models were used to investigate the association between intra-individual hormone changes and all-cause, CVD and cancer mortalities. Results: A total of 421 men (36.1%) died during the follow-up period. Men with most pronounced decline in total TS (<10th percentile) had a higher all-cause mortality risk compared to men within the 10th to 90th percentile (hazard ratio (HR): 1.60; 95% confdence interval (CI): 1.08-2.36). No consistent associations were seen in cause-specifc mortality analyses. Conclusion: Our study showed that higher mortality rates were seen among the men who had the most pronounced age-related decline in TS, independent of their baseline TS levels.

AB - Objective: Male aging is characterized by a decline in testosterone (TS) levels with a substantial variability between subjects. However, it is unclear whether differences in age-related changes in TS are associated with general health. We investigated associations between mortality and intra-individual changes in serum levels of total TS, SHBG, free TS and LH during a ten-year period with up to 18 years of registry follow-up. Design: 1167 men aged 30-60 years participating in the Danish Monitoring Trends and Determinants of Cardiovascular Disease (MONICA1) study and who had a follow-up examination ten years later (MONICA10) were included. From MONICA10, the men were followed up to 18 years (mean: 15.2 years) based on the information from national mortality registries via their unique personal ID numbers. Methods: Cox proportional hazard models were used to investigate the association between intra-individual hormone changes and all-cause, CVD and cancer mortalities. Results: A total of 421 men (36.1%) died during the follow-up period. Men with most pronounced decline in total TS (<10th percentile) had a higher all-cause mortality risk compared to men within the 10th to 90th percentile (hazard ratio (HR): 1.60; 95% confdence interval (CI): 1.08-2.36). No consistent associations were seen in cause-specifc mortality analyses. Conclusion: Our study showed that higher mortality rates were seen among the men who had the most pronounced age-related decline in TS, independent of their baseline TS levels.

KW - Journal Article

U2 - 10.1530/eje-17-0280

DO - 10.1530/eje-17-0280

M3 - Journal article

C2 - 29066571

SN - 0804-4643

VL - 178

SP - 121

EP - 128

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

ER -