Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV: the largest demographic study of 210 Danish patients

E Garnaes; K Kiss; L Andersen; M H Therkildsen; M B Franzmann; B Filtenborg-Barnkob; E Hoegdall; C B Lajer; E Andersen; L Specht; L Joenson; K Frederiksen; L Friis-Hansen; F C Nielsen; S K Kjaer; B Norrild; C von Buchwald

doi:10.1038/bjc.2015.198

Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV: the largest demographic study of 210 Danish patients

E Garnaes, K Kiss, L Andersen, M H Therkildsen, M B Franzmann, B Filtenborg-Barnkob, E Hoegdall, C B Lajer, E Andersen, L Specht, L Joenson, K Frederiksen, L Friis-Hansen, F C Nielsen, S K Kjaer, B Norrild, C von Buchwald

47 Citationer (Scopus)

Abstract

background: We assessed the development in the number of new base of tongue squamous-cell carcinoma (BSCC) cases per year in eastern Denmark from 2000 to 2010 and whether HPV may explain any observable increased incidence.
methods: We performed HPV DNA PCR and p16 immunohistochemistry analysis for all (n=210) BSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and the Danish Pathology Data Bank, and genotyped all HPV-positive specimens with amplicon-based next-generation sequencing.
results: The overall crude incidence of BSCCs increased significantly (5.4% per year) during the study period. This was explained by a significant increase in the number of HPV-positive BSCCs (8.1% per year), whereas the number of HPV-negative BSCCs did not increase significantly. The overall HPV prevalence was 51%, with HPV16 as the predominant HPV type.
conclusions: The increased number of HPV-positive BSCCs may explain the increasing incidence of BSCCs in eastern Denmark, 2000–2010.

Originalsprog	Engelsk
Tidsskrift	B J C
Vol/bind	113
Udgave nummer	1
Sider (fra-til)	131-4
Antal sider	4
ISSN	0007-0920
DOI	https://doi.org/10.1038/bjc.2015.198
Status	Udgivet - 30 jun. 2015

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Garnaes, E., Kiss, K., Andersen, L., Therkildsen, M. H., Franzmann, M. B., Filtenborg-Barnkob, B., Hoegdall, E., Lajer, C. B., Andersen, E., Specht, L., Joenson, L., Frederiksen, K., Friis-Hansen, L., Nielsen, F. C., Kjaer, S. K., Norrild, B., & von Buchwald, C. (2015). Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV: the largest demographic study of 210 Danish patients. B J C, 113(1), 131-4. https://doi.org/10.1038/bjc.2015.198

Garnaes, E, Kiss, K, Andersen, L, Therkildsen, MH, Franzmann, MB, Filtenborg-Barnkob, B, Hoegdall, E, Lajer, CB, Andersen, E, Specht, L, Joenson, L, Frederiksen, K, Friis-Hansen, L , Nielsen, FC , Kjaer, SK, Norrild, B & von Buchwald, C 2015, 'Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV: the largest demographic study of 210 Danish patients', B J C, bind 113, nr. 1, s. 131-4. https://doi.org/10.1038/bjc.2015.198

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title = "Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV: the largest demographic study of 210 Danish patients",

abstract = "We assessed the development in the number of new base of tongue squamous-cell carcinoma (BSCC) cases per year in eastern Denmark from 2000 to 2010 and whether HPV may explain any observable increased incidence.Methods:We performed HPV DNA PCR and p16 immunohistochemistry analysis for all (n=210) BSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and the Danish Pathology Data Bank, and genotyped all HPV-positive specimens with amplicon-based next-generation sequencing.Results:The overall crude incidence of BSCCs increased significantly (5.4% per year) during the study period. This was explained by a significant increase in the number of HPV-positive BSCCs (8.1% per year), whereas the number of HPV-negative BSCCs did not increase significantly. The overall HPV prevalence was 51%, with HPV16 as the predominant HPV type.Conclusions:The increased number of HPV-positive BSCCs may explain the increasing incidence of BSCCs in eastern Denmark, 2000-2010.",

keywords = "Alphapapillomavirus, Denmark, Humans, Incidence, Tongue Neoplasms",

author = "E Garnaes and K Kiss and L Andersen and Therkildsen, {M H} and Franzmann, {M B} and B Filtenborg-Barnkob and E Hoegdall and Lajer, {C B} and E Andersen and L Specht and L Joenson and K Frederiksen and L Friis-Hansen and Nielsen, {F C} and Kjaer, {S K} and B Norrild and {von Buchwald}, C",

year = "2015",

month = jun,

day = "30",

doi = "10.1038/bjc.2015.198",

language = "English",

volume = "113",

pages = "131--4",

journal = "B J C",

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TY - JOUR

T1 - Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV

T2 - the largest demographic study of 210 Danish patients

AU - Garnaes, E

AU - Kiss, K

AU - Andersen, L

AU - Therkildsen, M H

AU - Franzmann, M B

AU - Filtenborg-Barnkob, B

AU - Hoegdall, E

AU - Lajer, C B

AU - Andersen, E

AU - Specht, L

AU - Joenson, L

AU - Frederiksen, K

AU - Friis-Hansen, L

AU - Nielsen, F C

AU - Kjaer, S K

AU - Norrild, B

AU - von Buchwald, C

PY - 2015/6/30

Y1 - 2015/6/30

N2 - We assessed the development in the number of new base of tongue squamous-cell carcinoma (BSCC) cases per year in eastern Denmark from 2000 to 2010 and whether HPV may explain any observable increased incidence.Methods:We performed HPV DNA PCR and p16 immunohistochemistry analysis for all (n=210) BSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and the Danish Pathology Data Bank, and genotyped all HPV-positive specimens with amplicon-based next-generation sequencing.Results:The overall crude incidence of BSCCs increased significantly (5.4% per year) during the study period. This was explained by a significant increase in the number of HPV-positive BSCCs (8.1% per year), whereas the number of HPV-negative BSCCs did not increase significantly. The overall HPV prevalence was 51%, with HPV16 as the predominant HPV type.Conclusions:The increased number of HPV-positive BSCCs may explain the increasing incidence of BSCCs in eastern Denmark, 2000-2010.

AB - We assessed the development in the number of new base of tongue squamous-cell carcinoma (BSCC) cases per year in eastern Denmark from 2000 to 2010 and whether HPV may explain any observable increased incidence.Methods:We performed HPV DNA PCR and p16 immunohistochemistry analysis for all (n=210) BSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and the Danish Pathology Data Bank, and genotyped all HPV-positive specimens with amplicon-based next-generation sequencing.Results:The overall crude incidence of BSCCs increased significantly (5.4% per year) during the study period. This was explained by a significant increase in the number of HPV-positive BSCCs (8.1% per year), whereas the number of HPV-negative BSCCs did not increase significantly. The overall HPV prevalence was 51%, with HPV16 as the predominant HPV type.Conclusions:The increased number of HPV-positive BSCCs may explain the increasing incidence of BSCCs in eastern Denmark, 2000-2010.

KW - Alphapapillomavirus

KW - Denmark

KW - Humans

KW - Incidence

KW - Tongue Neoplasms

U2 - 10.1038/bjc.2015.198

DO - 10.1038/bjc.2015.198

M3 - Journal article

C2 - 26042932

SN - 0007-0920

VL - 113

SP - 131

EP - 134

JO - B J C

JF - B J C

IS - 1

ER -

Increasing incidence of base of tongue cancers from 2000 to 2010 due to HPV: the largest demographic study of 210 Danish patients

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