Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis

Matilda Degn; Signe Modvig; Beatrice Dyring-Andersen; Charlotte M Bonefeld; Jette Lautrup Fredriksen; Carsten Geisler; Marina R von Essen

doi:10.1177/1352458515609795

Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis

Matilda Degn, Signe Modvig, Beatrice Dyring-Andersen, Charlotte M Bonefeld, Jette Lautrup Fredriksen, Carsten Geisler, Marina R von Essen

7 Citationer (Scopus)

Abstract

BACKGROUND: Inflammatory cytokines produced by cells of the immune system are believed to play a central role in the pathogenesis of multiple sclerosis (MS). Innate lymphoid cells (ILCs) have been shown to produce and secrete a wide range of the cytokines involved in MS pathogenesis; however, a possible implication of ILCs in MS development and disease progression has not been investigated.

OBJECTIVE: With this study, we aimed to clarify a potential role of ILCs in the early stages of MS.

METHODS AND RESULTS: Using flow cytometry, we analysed the prevalence and phenotype of ILCs in the cerebrospinal fluid (CSF) of patients experiencing their first or second demyelinating event. We found a substantial increase in both frequency and number of ILCs, in particular the LTi subset, as compared to healthy controls. We also found an association between CSF pleocytosis and an increased frequency of LTi cells in the CSF, suggesting a favoured recruitment of blood derived LTi cells.

CONCLUSION: Our data suggests a role for ILCs, and in particular the LTi subset, in the early stages of MS. This finding represents an important contribution to the understanding of early inflammation in MS, and adds new knowledge beneficial for future MS therapies.

Originalsprog	Engelsk
Tidsskrift	Multiple Sclerosis Journal
Vol/bind	22
Udgave nummer	8
Sider (fra-til)	1013-1020
Antal sider	8
ISSN	1352-4585
DOI	https://doi.org/10.1177/1352458515609795
Status	Udgivet - 1 jul. 2016

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10.1177/1352458515609795

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title = "Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis",

abstract = "BACKGROUND: Inflammatory cytokines produced by cells of the immune system are believed to play a central role in the pathogenesis of multiple sclerosis (MS). Innate lymphoid cells (ILCs) have been shown to produce and secrete a wide range of the cytokines involved in MS pathogenesis; however, a possible implication of ILCs in MS development and disease progression has not been investigated.OBJECTIVE: With this study, we aimed to clarify a potential role of ILCs in the early stages of MS.METHODS AND RESULTS: Using flow cytometry, we analysed the prevalence and phenotype of ILCs in the cerebrospinal fluid (CSF) of patients experiencing their first or second demyelinating event. We found a substantial increase in both frequency and number of ILCs, in particular the LTi subset, as compared to healthy controls. We also found an association between CSF pleocytosis and an increased frequency of LTi cells in the CSF, suggesting a favoured recruitment of blood derived LTi cells.CONCLUSION: Our data suggests a role for ILCs, and in particular the LTi subset, in the early stages of MS. This finding represents an important contribution to the understanding of early inflammation in MS, and adds new knowledge beneficial for future MS therapies.",

author = "Matilda Degn and Signe Modvig and Beatrice Dyring-Andersen and Bonefeld, {Charlotte M} and Fredriksen, {Jette Lautrup} and Carsten Geisler and {von Essen}, {Marina R}",

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doi = "10.1177/1352458515609795",

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TY - JOUR

T1 - Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis

AU - Degn, Matilda

AU - Modvig, Signe

AU - Dyring-Andersen, Beatrice

AU - Bonefeld, Charlotte M

AU - Fredriksen, Jette Lautrup

AU - Geisler, Carsten

AU - von Essen, Marina R

PY - 2016/7/1

Y1 - 2016/7/1

N2 - BACKGROUND: Inflammatory cytokines produced by cells of the immune system are believed to play a central role in the pathogenesis of multiple sclerosis (MS). Innate lymphoid cells (ILCs) have been shown to produce and secrete a wide range of the cytokines involved in MS pathogenesis; however, a possible implication of ILCs in MS development and disease progression has not been investigated.OBJECTIVE: With this study, we aimed to clarify a potential role of ILCs in the early stages of MS.METHODS AND RESULTS: Using flow cytometry, we analysed the prevalence and phenotype of ILCs in the cerebrospinal fluid (CSF) of patients experiencing their first or second demyelinating event. We found a substantial increase in both frequency and number of ILCs, in particular the LTi subset, as compared to healthy controls. We also found an association between CSF pleocytosis and an increased frequency of LTi cells in the CSF, suggesting a favoured recruitment of blood derived LTi cells.CONCLUSION: Our data suggests a role for ILCs, and in particular the LTi subset, in the early stages of MS. This finding represents an important contribution to the understanding of early inflammation in MS, and adds new knowledge beneficial for future MS therapies.

AB - BACKGROUND: Inflammatory cytokines produced by cells of the immune system are believed to play a central role in the pathogenesis of multiple sclerosis (MS). Innate lymphoid cells (ILCs) have been shown to produce and secrete a wide range of the cytokines involved in MS pathogenesis; however, a possible implication of ILCs in MS development and disease progression has not been investigated.OBJECTIVE: With this study, we aimed to clarify a potential role of ILCs in the early stages of MS.METHODS AND RESULTS: Using flow cytometry, we analysed the prevalence and phenotype of ILCs in the cerebrospinal fluid (CSF) of patients experiencing their first or second demyelinating event. We found a substantial increase in both frequency and number of ILCs, in particular the LTi subset, as compared to healthy controls. We also found an association between CSF pleocytosis and an increased frequency of LTi cells in the CSF, suggesting a favoured recruitment of blood derived LTi cells.CONCLUSION: Our data suggests a role for ILCs, and in particular the LTi subset, in the early stages of MS. This finding represents an important contribution to the understanding of early inflammation in MS, and adds new knowledge beneficial for future MS therapies.

U2 - 10.1177/1352458515609795

DO - 10.1177/1352458515609795

M3 - Journal article

C2 - 26453677

SN - 1352-4585

VL - 22

SP - 1013

EP - 1020

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 8

ER -

Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis

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