Increased EMG intermuscular coherence and reduced signal complexity in Parkinson's disease

TY - JOUR

T1 - Increased EMG intermuscular coherence and reduced signal complexity in Parkinson's disease

AU - Flood, Matthew W

AU - Jensen, Bente Rona

AU - Malling, Anne-Sofie

AU - Lowery, Madeleine M

N1 - CURIS 2019 NEXS 009

PY - 2019/2

Y1 - 2019/2

N2 - Objectives: To investigate differences in surface electromyography (EMG) features in individuals with idiopathic Parkinson's disease (PD) and aged-matched controls.Methods: Surface EMG was recorded during isometric leg extension in PD patients prior to, and after undergoing a locomotor training programme, and in aged-matched controls. Differences in EMG structure were quantified using determinism (%DET), sample entropy (SampEn) and intermuscular coherence.Results: %DET was significantly higher, and SampEn significantly lower, in PD patients. Intermuscular coherence was also significantly higher in the PD group in theta, alpha and beta frequency bands. %DET increased and SampEn decreased with increasing Movement-Disorder-Society UPDRS scores, while theta band coherence was significantly correlated with total MDS-UPDRS scores and torque variance. Neither %DET, SampEn nor intermuscular coherence changed in response to training.Conclusions: The differences observed are consistent with increased synchrony among motor units within and across leg muscles in PD. Differences between EMG signals recorded from the PD and control groups persisted post-therapy, after improvements in walking capacity occurred.Significance: These results provide insight into changes in motoneuron activity in PD, demonstrate increased beta band intramuscular coherence in PD for the first time, and support the development of quantitative biomarkers for PD based on advanced surface EMG features.

AB - Objectives: To investigate differences in surface electromyography (EMG) features in individuals with idiopathic Parkinson's disease (PD) and aged-matched controls.Methods: Surface EMG was recorded during isometric leg extension in PD patients prior to, and after undergoing a locomotor training programme, and in aged-matched controls. Differences in EMG structure were quantified using determinism (%DET), sample entropy (SampEn) and intermuscular coherence.Results: %DET was significantly higher, and SampEn significantly lower, in PD patients. Intermuscular coherence was also significantly higher in the PD group in theta, alpha and beta frequency bands. %DET increased and SampEn decreased with increasing Movement-Disorder-Society UPDRS scores, while theta band coherence was significantly correlated with total MDS-UPDRS scores and torque variance. Neither %DET, SampEn nor intermuscular coherence changed in response to training.Conclusions: The differences observed are consistent with increased synchrony among motor units within and across leg muscles in PD. Differences between EMG signals recorded from the PD and control groups persisted post-therapy, after improvements in walking capacity occurred.Significance: These results provide insight into changes in motoneuron activity in PD, demonstrate increased beta band intramuscular coherence in PD for the first time, and support the development of quantitative biomarkers for PD based on advanced surface EMG features.

KW - Faculty of Science

KW - Electromyography

KW - Coherence

KW - Determinism

KW - Entropy

KW - Synchronization

KW - Parkinson’s disease

U2 - 10.1016/j.clinph.2018.10.023

DO - 10.1016/j.clinph.2018.10.023

M3 - Journal article

C2 - 30583273

SN - 1388-2457

VL - 130

SP - 259

EP - 269

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 2

ER -