Incidental lung cancers and positive computed tomography images in people living with HIV

Andreas Ronit; Thomas Kristensen; Ditte M. Klitbo; Marco Gelpi; Anna Kalhauge; Thomas Benfield; Jan Gerstoft; Jens Lundgren; Jørgen Vestbo; Klaus F. Kofoed; Susanne D. Nielsen

doi:10.1097/QAD.0000000000001600

Incidental lung cancers and positive computed tomography images in people living with HIV

Andreas Ronit, Thomas Kristensen, Ditte M. Klitbo, Marco Gelpi, Anna Kalhauge, Thomas Benfield, Jan Gerstoft, Jens Lundgren, Jørgen Vestbo, Klaus F. Kofoed, Susanne D. Nielsen^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

5 Citationer (Scopus)

Abstract

Objective: Lung cancer screening with low-dose computed tomography (LDCT) of high-risk groups in the general population is recommended by several authorities. This may not be feasible in people living with HIV (PLWHIV) due to higher prevalence of nodules. We therefore assessed the prevalence of positive computed tomography (CT) images and lung cancers in PLWHIV. Design: The Copenhagen comorbidity in HIV infection (COCOMO) study is an observational, longitudinal cohort study. Single-round LDCT was performed with subsequent clinical follow-up (NCT02382822). Method: Outcomes included histology-proven lung cancer identified by LDCT and positive CT images (noncalcified nodules) in the entire cohort and in the high-risk group (>50 years of age and >30 pack-years). We also assessed the procedures and adverse events, and clinical factors associated with a positive CT image. Results: LDCT was performed in 901 patients, including 113 at high risk for lung cancer. A positive image was found in 28 (3.1% of the entire cohort and 9.7% of the high-risk group). Nine patients (all in the high-risk group) had invasive procedures undertaken with no serious adverse events. Lung cancer (stages IA, IIA, and IIIA) was diagnosed in three patients from the high-risk group (2.7%). CD4 + cell count less than 500 cells/μl and CD4 + nadir less than 200 cells/μl were each independently associated with increased odds of a positive image odds ratio 2.32 [95% confidence interval: 1.01-5.13, P==0.04] and odds ratio 2.63 [95% confidence interval: 1.13-6.66, P==0.03]. Conclusion: Randomized LDCT screening trials in PLWHIV are nonexistent, but these findings are comparable with screening rounds from the general population in terms of prevalence of lung cancer and positive CT images.

Originalsprog	Engelsk
Tidsskrift	AIDS
Vol/bind	31
Udgave nummer	14
Sider (fra-til)	1973-1977
Antal sider	5
ISSN	0269-9370
DOI	https://doi.org/10.1097/QAD.0000000000001600
Status	Udgivet - sep. 2017

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@article{6aa1664c8d6440b8a0ac4c5627f79c42,

title = "Incidental lung cancers and positive computed tomography images in people living with HIV",

abstract = "Objective: Lung cancer screening with low-dose computed tomography (LDCT) of high-risk groups in the general population is recommended by several authorities. This may not be feasible in people living with HIV (PLWHIV) due to higher prevalence of nodules. We therefore assessed the prevalence of positive computed tomography (CT) images and lung cancers in PLWHIV. Design: The Copenhagen comorbidity in HIV infection (COCOMO) study is an observational, longitudinal cohort study. Single-round LDCT was performed with subsequent clinical follow-up (NCT02382822). Method: Outcomes included histology-proven lung cancer identified by LDCT and positive CT images (noncalcified nodules) in the entire cohort and in the high-risk group (>50 years of age and >30 pack-years). We also assessed the procedures and adverse events, and clinical factors associated with a positive CT image. Results: LDCT was performed in 901 patients, including 113 at high risk for lung cancer. A positive image was found in 28 (3.1% of the entire cohort and 9.7% of the high-risk group). Nine patients (all in the high-risk group) had invasive procedures undertaken with no serious adverse events. Lung cancer (stages IA, IIA, and IIIA) was diagnosed in three patients from the high-risk group (2.7%). CD4 + cell count less than 500 cells/μl and CD4 + nadir less than 200 cells/μl were each independently associated with increased odds of a positive image odds ratio 2.32 [95% confidence interval: 1.01-5.13, P==0.04] and odds ratio 2.63 [95% confidence interval: 1.13-6.66, P==0.03]. Conclusion: Randomized LDCT screening trials in PLWHIV are nonexistent, but these findings are comparable with screening rounds from the general population in terms of prevalence of lung cancer and positive CT images.",

keywords = "computed tomography, HIV, incidental findings, lung cancer, nodules",

author = "Andreas Ronit and Thomas Kristensen and Klitbo, {Ditte M.} and Marco Gelpi and Anna Kalhauge and Thomas Benfield and Jan Gerstoft and Jens Lundgren and J{\o}rgen Vestbo and Kofoed, {Klaus F.} and Nielsen, {Susanne D.}",

year = "2017",

month = sep,

doi = "10.1097/QAD.0000000000001600",

language = "English",

volume = "31",

pages = "1973--1977",

journal = "AIDS, Supplement",

issn = "1350-2840",

publisher = "Lippincott Williams & Wilkins",

number = "14",

}

TY - JOUR

T1 - Incidental lung cancers and positive computed tomography images in people living with HIV

AU - Ronit, Andreas

AU - Kristensen, Thomas

AU - Klitbo, Ditte M.

AU - Gelpi, Marco

AU - Kalhauge, Anna

AU - Benfield, Thomas

AU - Gerstoft, Jan

AU - Lundgren, Jens

AU - Vestbo, Jørgen

AU - Kofoed, Klaus F.

AU - Nielsen, Susanne D.

PY - 2017/9

Y1 - 2017/9

N2 - Objective: Lung cancer screening with low-dose computed tomography (LDCT) of high-risk groups in the general population is recommended by several authorities. This may not be feasible in people living with HIV (PLWHIV) due to higher prevalence of nodules. We therefore assessed the prevalence of positive computed tomography (CT) images and lung cancers in PLWHIV. Design: The Copenhagen comorbidity in HIV infection (COCOMO) study is an observational, longitudinal cohort study. Single-round LDCT was performed with subsequent clinical follow-up (NCT02382822). Method: Outcomes included histology-proven lung cancer identified by LDCT and positive CT images (noncalcified nodules) in the entire cohort and in the high-risk group (>50 years of age and >30 pack-years). We also assessed the procedures and adverse events, and clinical factors associated with a positive CT image. Results: LDCT was performed in 901 patients, including 113 at high risk for lung cancer. A positive image was found in 28 (3.1% of the entire cohort and 9.7% of the high-risk group). Nine patients (all in the high-risk group) had invasive procedures undertaken with no serious adverse events. Lung cancer (stages IA, IIA, and IIIA) was diagnosed in three patients from the high-risk group (2.7%). CD4 + cell count less than 500 cells/μl and CD4 + nadir less than 200 cells/μl were each independently associated with increased odds of a positive image odds ratio 2.32 [95% confidence interval: 1.01-5.13, P==0.04] and odds ratio 2.63 [95% confidence interval: 1.13-6.66, P==0.03]. Conclusion: Randomized LDCT screening trials in PLWHIV are nonexistent, but these findings are comparable with screening rounds from the general population in terms of prevalence of lung cancer and positive CT images.

AB - Objective: Lung cancer screening with low-dose computed tomography (LDCT) of high-risk groups in the general population is recommended by several authorities. This may not be feasible in people living with HIV (PLWHIV) due to higher prevalence of nodules. We therefore assessed the prevalence of positive computed tomography (CT) images and lung cancers in PLWHIV. Design: The Copenhagen comorbidity in HIV infection (COCOMO) study is an observational, longitudinal cohort study. Single-round LDCT was performed with subsequent clinical follow-up (NCT02382822). Method: Outcomes included histology-proven lung cancer identified by LDCT and positive CT images (noncalcified nodules) in the entire cohort and in the high-risk group (>50 years of age and >30 pack-years). We also assessed the procedures and adverse events, and clinical factors associated with a positive CT image. Results: LDCT was performed in 901 patients, including 113 at high risk for lung cancer. A positive image was found in 28 (3.1% of the entire cohort and 9.7% of the high-risk group). Nine patients (all in the high-risk group) had invasive procedures undertaken with no serious adverse events. Lung cancer (stages IA, IIA, and IIIA) was diagnosed in three patients from the high-risk group (2.7%). CD4 + cell count less than 500 cells/μl and CD4 + nadir less than 200 cells/μl were each independently associated with increased odds of a positive image odds ratio 2.32 [95% confidence interval: 1.01-5.13, P==0.04] and odds ratio 2.63 [95% confidence interval: 1.13-6.66, P==0.03]. Conclusion: Randomized LDCT screening trials in PLWHIV are nonexistent, but these findings are comparable with screening rounds from the general population in terms of prevalence of lung cancer and positive CT images.

KW - computed tomography

KW - HIV

KW - incidental findings

KW - lung cancer

KW - nodules

U2 - 10.1097/QAD.0000000000001600

DO - 10.1097/QAD.0000000000001600

M3 - Journal article

C2 - 28857778

AN - SCOPUS:85028726138

SN - 1350-2840

VL - 31

SP - 1973

EP - 1977

JO - AIDS, Supplement

JF - AIDS, Supplement

IS - 14

ER -

Incidental lung cancers and positive computed tomography images in people living with HIV

Abstract

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