TY - JOUR
T1 - Incidence of systemic lupus erythematosus and lupus nephritis in Denmark
T2 - A nationwide cohort study
AU - Hermansen, Marie-Louise From
AU - Lindhardsen, Jesper
AU - Torp-Pedersen, Christian
AU - Faurschou, Mikkel
AU - Jacobsen, Søren
PY - 2016
Y1 - 2016
N2 - Objective. To determine the incidence of systemic lupus erythematosus (SLE) and SLE with concomitant or subsequent lupus nephritis (LN) in Denmark during 1995.2011, using data from the Danish National Patient Registry (NPR). Methods. To assess the incidence of SLE, we identified all persons aged . 18 years in the NPR with at least 1 International Classification of Diseases, 10th ed (ICD-10) code of SLE and at least 365 days of followup under this diagnosis. Identification of LN cases was based on fulfillment of these criteria and . 1 registration under an ICD-10 code of nephritis concomitantly with or after first SLE registration. Results. The overall annual incidence rate per 100,000 for SLE was 2.35 (95% CI 2.24.2.49); 0.69 (95% CI 0.60.0.78) for men and 3.96 (95% CI 3.75.4.17) for women. For LN, the mean annual incidence rate per 100,000 was estimated to be 0.45 (95% CI 0.38.0.53); 0.20 (95% CI 0.13.0.28) for men and 0.69 (95% CI 0.57.0.83) for women. The differences in SLE incidence rates between sexes decreased by age, and the incidence did not differ between men and women after the age of 60 years for LN. The estimated incidences showed no trends by calendar time. Estimated overall point prevalence (December 31, 2011) per 100,000 was 45.2 (95% CI 43.3.47.4) and 6.4 (95% CI 5.7.7.2) for SLE and LN, respectively. Conclusion. Our Danish population-based data showed a stable incidence of SLE and LN. As expected, we found higher incidence rates among women than among men, particularly in younger persons.
AB - Objective. To determine the incidence of systemic lupus erythematosus (SLE) and SLE with concomitant or subsequent lupus nephritis (LN) in Denmark during 1995.2011, using data from the Danish National Patient Registry (NPR). Methods. To assess the incidence of SLE, we identified all persons aged . 18 years in the NPR with at least 1 International Classification of Diseases, 10th ed (ICD-10) code of SLE and at least 365 days of followup under this diagnosis. Identification of LN cases was based on fulfillment of these criteria and . 1 registration under an ICD-10 code of nephritis concomitantly with or after first SLE registration. Results. The overall annual incidence rate per 100,000 for SLE was 2.35 (95% CI 2.24.2.49); 0.69 (95% CI 0.60.0.78) for men and 3.96 (95% CI 3.75.4.17) for women. For LN, the mean annual incidence rate per 100,000 was estimated to be 0.45 (95% CI 0.38.0.53); 0.20 (95% CI 0.13.0.28) for men and 0.69 (95% CI 0.57.0.83) for women. The differences in SLE incidence rates between sexes decreased by age, and the incidence did not differ between men and women after the age of 60 years for LN. The estimated incidences showed no trends by calendar time. Estimated overall point prevalence (December 31, 2011) per 100,000 was 45.2 (95% CI 43.3.47.4) and 6.4 (95% CI 5.7.7.2) for SLE and LN, respectively. Conclusion. Our Danish population-based data showed a stable incidence of SLE and LN. As expected, we found higher incidence rates among women than among men, particularly in younger persons.
KW - EPIDEMIOLOGY
KW - INCIDENCE
KW - LUPUS NEPHRITIS
KW - SYSTEMIC LUPUS ERYTHEMATOSUS
U2 - 10.3899/jrheum.151221
DO - 10.3899/jrheum.151221
M3 - Journal article
C2 - 27134247
AN - SCOPUS:84977260872
SN - 0315-162X
VL - 43
SP - 1335
EP - 1339
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 7
ER -