Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015

Martin T. Jepsen; Ramona Trebbien; Hanne Dorthe Emborg; Tyra G. Krause; Kristian Schønning; Marianne Voldstedlund; Jens Nielsen; Thea Kølsen Fischer

doi:10.2807/1560-7917.ES.2018.23.3.17-00163

Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015

Martin T. Jepsen, Ramona Trebbien, Hanne Dorthe Emborg, Tyra G. Krause, Kristian Schønning, Marianne Voldstedlund, Jens Nielsen, Thea Kølsen Fischer^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

18 Citationer (Scopus)

35 Downloads (Pure)

Abstract

For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medi-cal-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.

Originalsprog	Engelsk
Artikelnummer	17-00163
Tidsskrift	Eurosurveillance
Vol/bind	23
Udgave nummer	3
Antal sider	8
ISSN	1025-496X
DOI	https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00163
Status	Udgivet - 2018

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10.2807/1560-7917.ES.2018.23.3.17-00163Licens: CC BY

Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015Forlagets udgivne version, 227 KBLicens: CC BY

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title = "Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015",

abstract = "For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medi-cal-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.",

author = "Jepsen, {Martin T.} and Ramona Trebbien and Emborg, {Hanne Dorthe} and Krause, {Tyra G.} and Kristian Sch{\o}nning and Marianne Voldstedlund and Jens Nielsen and Fischer, {Thea K{\o}lsen}",

year = "2018",

doi = "10.2807/1560-7917.ES.2018.23.3.17-00163",

language = "English",

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journal = "Eurosurveillance",

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TY - JOUR

T1 - Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015

AU - Jepsen, Martin T.

AU - Trebbien, Ramona

AU - Emborg, Hanne Dorthe

AU - Krause, Tyra G.

AU - Schønning, Kristian

AU - Voldstedlund, Marianne

AU - Nielsen, Jens

AU - Fischer, Thea Kølsen

PY - 2018

Y1 - 2018

N2 - For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medi-cal-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.

AB - For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medi-cal-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.

U2 - 10.2807/1560-7917.ES.2018.23.3.17-00163

DO - 10.2807/1560-7917.ES.2018.23.3.17-00163

M3 - Journal article

C2 - 29386093

AN - SCOPUS:85041923526

SN - 1025-496X

VL - 23

JO - Eurosurveillance

JF - Eurosurveillance

IS - 3

M1 - 17-00163

ER -

Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015

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