@article{9803eaf0359f11df8ed1000ea68e967b,
title = "In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts",
abstract = "Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.",
author = "Perentes, {Jean Y} and McKee, {Trevor D} and Ley, {Carsten D} and Hannah Mathiew and Michelle Dawson and Padera, {Timothy P} and Munn, {Lance L} and Jain, {Rakesh K} and Yves Boucher",
note = "Keywords: Animals; Cell Line, Tumor; Cell Movement; Collagen; Extracellular Matrix; Fibroblasts; Humans; Image Enhancement; Integrin beta Chains; Mice; Mice, Transgenic; Microscopy, Confocal; Relaxin; Soft Tissue Neoplasms; Stromal Cells",
year = "2009",
doi = "10.1038/nmeth.1295",
language = "English",
volume = "6",
pages = "143--5",
journal = "Nature Methods",
issn = "1548-7091",
publisher = "nature publishing group",
number = "2",
}