In silico identification of novel G protein-coupled receptors

TY - CHAP

T1 - In silico identification of novel G protein-coupled receptors

AU - Davies, Matthew N

AU - Gloriam, David E

AU - Flower, Darren R

N1 - Part 1: The G protein-coupled receptor in the genome Keywords: receptor classification; genomics; machine learning; in silico

PY - 2011

Y1 - 2011

N2 - The G protein-coupled receptors (GPCRs) form the largest and most multi-functional protein-superfamilies known. From a drug discovery and pharmaceutical industry perspective, the GPCRs are among the most commercially and economically important groups of proteins yet identified, since they have so many vital metabolic functions and interact with such a diversity of ligands. Many distinct methodologies have been proposed to classify the GPCRs: motif-based techniques, machine learning, and several alignment-free techniques have all been used successful in this regard. This chapter reviews the available methodologies for classifying GPCRs. In particular, we allude to several innate problems in developing such approaches, such as the lack of sequence similarity between the six GPCR classes and the low sequence similarity of many newly identified family members to other GPCRs.

AB - The G protein-coupled receptors (GPCRs) form the largest and most multi-functional protein-superfamilies known. From a drug discovery and pharmaceutical industry perspective, the GPCRs are among the most commercially and economically important groups of proteins yet identified, since they have so many vital metabolic functions and interact with such a diversity of ligands. Many distinct methodologies have been proposed to classify the GPCRs: motif-based techniques, machine learning, and several alignment-free techniques have all been used successful in this regard. This chapter reviews the available methodologies for classifying GPCRs. In particular, we allude to several innate problems in developing such approaches, such as the lack of sequence similarity between the six GPCR classes and the low sequence similarity of many newly identified family members to other GPCRs.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/978-1-61779-179-6_1

DO - 10.1007/978-1-61779-179-6_1

M3 - Book chapter

SN - 978-1-61779-178-9

VL - 60

T3 - Neuromethods

SP - 3

EP - 18

BT - Methods for the discovery and characterization of G protein-coupled receptors

A2 - Stevens, Craig W

PB - Humana Press

CY - New York

ER -