Important options available--from start to finish--for translating proteomics results to clinical chemistry

Niels H H Heegaard; Ole Østergaard; Justyna M C Bahl; Martin Overgaard; Hans C Beck; Lars Melholt Rasmussen; Martin Røssel Larsen

doi:10.1002/prca.201400137

Important options available--from start to finish--for translating proteomics results to clinical chemistry

Niels H H Heegaard, Ole Østergaard, Justyna M C Bahl, Martin Overgaard, Hans C Beck, Lars Melholt Rasmussen, Martin Røssel Larsen

7 Citationer (Scopus)

Abstract

In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feeds assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry.

Originalsprog	Engelsk
Tidsskrift	Proteomics - Clinical Applications
Vol/bind	9
Udgave nummer	1-2
Sider (fra-til)	235-52
Antal sider	18
ISSN	1862-8346
DOI	https://doi.org/10.1002/prca.201400137
Status	Udgivet - 1 feb. 2015

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10.1002/prca.201400137

Citationsformater

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title = "Important options available--from start to finish--for translating proteomics results to clinical chemistry",

abstract = "In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feeds assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry. ",

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author = "Heegaard, {Niels H H} and Ole {\O}stergaard and Bahl, {Justyna M C} and Martin Overgaard and Beck, {Hans C} and Rasmussen, {Lars Melholt} and Larsen, {Martin R{\o}ssel}",

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AU - Heegaard, Niels H H

AU - Østergaard, Ole

AU - Bahl, Justyna M C

AU - Overgaard, Martin

AU - Beck, Hans C

AU - Rasmussen, Lars Melholt

AU - Larsen, Martin Røssel

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N2 - In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feeds assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry.

AB - In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feeds assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry.

KW - Biomarkers/analysis

KW - Clinical Medicine

KW - Humans

KW - Proteome/analysis

KW - Proteomics/methods

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DO - 10.1002/prca.201400137

M3 - Review

C2 - 25472910

SN - 1862-8346

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JO - Proteomics - Clinical Applications

JF - Proteomics - Clinical Applications

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ER -

Important options available--from start to finish--for translating proteomics results to clinical chemistry

Abstract

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