TY - JOUR
T1 - Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma
T2 - Molecular Networks and Biological Concepts
AU - Raggi, Chiara
AU - Invernizzi, Pietro
AU - Andersen, Jesper Bøje
N1 - Copyright © 2014. Published by Elsevier B.V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Summary Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying the diversity of CCA growth patterns remain a key issue of clinical concern. Crucial questions comprise the nature of the CCA-origin, the initial target for cellular transformation as well as the relationship with the cancer stem cells (CSC) concept. Additionally, since CCA often develops in the context of an inflammatory milieu (cirrhosis and cholangitis), the stromal compartment or tumour microenvironment (TME) likely promotes initiation and progression of this malignancy, contributing to its heterogeneity. This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA.
AB - Summary Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying the diversity of CCA growth patterns remain a key issue of clinical concern. Crucial questions comprise the nature of the CCA-origin, the initial target for cellular transformation as well as the relationship with the cancer stem cells (CSC) concept. Additionally, since CCA often develops in the context of an inflammatory milieu (cirrhosis and cholangitis), the stromal compartment or tumour microenvironment (TME) likely promotes initiation and progression of this malignancy, contributing to its heterogeneity. This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA.
U2 - 10.1016/j.jhep.2014.09.007
DO - 10.1016/j.jhep.2014.09.007
M3 - Journal article
C2 - 25220250
SN - 0168-8278
JO - Journal of Hepatology
JF - Journal of Hepatology
ER -
