Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate

TY - JOUR

T1 - Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate

AU - Gaede, Peter

AU - Hansen, Henrik Post

AU - Parving, Hans-Henrik

AU - Pedersen, Oluf

PY - 2003

Y1 - 2003

N2 - Low-dose treatment with acetylsalicylic acid (ASA) is widely recommended to type 2 diabetic patients as primary prevention against cardiovascular disease. High-dose treatment with cyclooxygenase inhibitors reduces urinary albumin excretion rate (AER) in type 1 diabetic patients with micro- or macroalbuminuria. Whether a similar effect on AER exists during low-dose ASA treatment, which may confound the diagnosis and monitoring of micro- and macroalbuminuria in type 2 diabetic patients, remains to be elucidated.

AB - Low-dose treatment with acetylsalicylic acid (ASA) is widely recommended to type 2 diabetic patients as primary prevention against cardiovascular disease. High-dose treatment with cyclooxygenase inhibitors reduces urinary albumin excretion rate (AER) in type 1 diabetic patients with micro- or macroalbuminuria. Whether a similar effect on AER exists during low-dose ASA treatment, which may confound the diagnosis and monitoring of micro- and macroalbuminuria in type 2 diabetic patients, remains to be elucidated.

KW - Adult

KW - Aged

KW - Albuminuria

KW - Aspirin

KW - Cardiovascular Diseases

KW - Cross-Over Studies

KW - Diabetes Mellitus, Type 2

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Female

KW - Fibrinolytic Agents

KW - Glomerular Filtration Rate

KW - Hemodynamics

KW - Humans

KW - Kidney

KW - Male

KW - Middle Aged

KW - Time Factors

M3 - Journal article

C2 - 12584276

SN - 0931-0509

VL - 18

SP - 539

EP - 542

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - 3

ER -