Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings

Heidi Hopkins; Katia J Bruxvoort; Matthew E Cairns; Clare I R Chandler; Baptiste Leurent; Evelyn K Ansah; Frank Baiden; Kimberly A Baltzell; Anders Björkman; Helen E D Burchett; Siân E Clarke; Deborah D DiLiberto; Kristina Elfving; Catherine Goodman; Kristian S Hansen; S Patrick Kachur; Sham Lal; David G Lalloo; Toby Leslie; Pascal Magnussen; Lindsay Mangham Jefferies; Andreas Mårtensson; Ismail Mayan; Anthony K Mbonye; Mwinyi I Msellem; Obinna E Onwujekwe; Seth Owusu-Agyei; Hugh Reyburn; Mark W Rowland; Delér Shakely; Lasse S Vestergaard; Jayne Webster; Virginia L Wiseman; Shunmay Yeung; David Schellenberg; Sarah G Staedke; Christopher J M Whitty

doi:10.1136/bmj.j1054

Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings

Heidi Hopkins, Katia J Bruxvoort, Matthew E Cairns, Clare I R Chandler, Baptiste Leurent, Evelyn K Ansah, Frank Baiden, Kimberly A Baltzell, Anders Björkman, Helen E D Burchett, Siân E Clarke, Deborah D DiLiberto, Kristina Elfving, Catherine Goodman, Kristian S Hansen, S Patrick Kachur, Sham Lal, David G Lalloo, Toby Leslie, Pascal MagnussenLindsay Mangham Jefferies, Andreas Mårtensson, Ismail Mayan, Anthony K Mbonye, Mwinyi I Msellem, Obinna E Onwujekwe, Seth Owusu-Agyei, Hugh Reyburn, Mark W Rowland, Delér Shakely, Lasse S Vestergaard, Jayne Webster, Virginia L Wiseman, Shunmay Yeung, David Schellenberg, Sarah G Staedke, Christopher J M Whitty

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Abstract

Objectives To examine the impact of use of rapid diagnostic tests for malaria on prescribing of antimicrobials, specifically antibiotics, for acute febrile illness in Africa and Asia.Design Analysisof nine preselected linked and codesigned observational and randomised studies (eight cluster or individually randomised trials and one observational study).Setting Public and private healthcare settings, 2007-13, in Afghanistan, Cameroon, Ghana, Nigeria, Tanzania, and Uganda.Participants 522 480 children and adults with acute febrile illness.Interventions Rapid diagnostic tests for malaria.Main outcome measures Proportions of patients for whom an antibiotic was prescribed in trial groups who had undergone rapid diagnostic testing compared with controls and in patients with negative test results compared with patients with positive results. A secondary aim compared classes of antibiotics prescribed in different settings.Results Antibiotics were prescribed to 127 052/238 797 (53%) patients in control groups and 167 714/283 683 (59%) patients in intervention groups. Antibiotics were prescribed to 40% (35 505/89 719) of patients with a positive test result for malaria and to 69% (39 400/57 080) of those with a negative result. All but one study showed a trend toward more antibiotic prescribing in groups who underwent rapid diagnostic tests. Random effects meta-analysis of the trials showed that the overall risk of antibiotic prescription was 21% higher (95% confidence interval 7% to 36%) in intervention settings. In most intervention settings, patients with negative test results received more antibiotic prescriptions than patients with positive results for all the most commonly used classes: penicillins, trimethoprim-sulfamethoxazole (one exception), tetracyclines, and metronidazole.Conclusions Introduction of rapid diagnostic tests for malaria to reduce unnecessary use of antimalarials-a beneficial public health outcome-could drive up untargeted use of antibiotics. That 69% of patients were prescribed antibiotics when test results were negative probably represents overprescription.This included antibiotics from several classes, including those like metronidazole that are seldom appropriate for febrile illness, across varied clinical, health system, and epidemiological settings. It is often assumed that better disease specific diagnostics will reduce antimicrobial overuse, but they might simply shift it from one antimicrobial class to another. Current global implementation of malaria testing might increase untargeted antibiotic use and must be examined.

Originalsprog	Engelsk
Artikelnummer	j1054
Tidsskrift	The BMJ
Vol/bind	356
Antal sider	10
ISSN	0959-8146
DOI	https://doi.org/10.1136/bmj.j1054 https://doi.org/10.1136/bmj.j3168
Status	Udgivet - 2017

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10.1136/bmj.j1054Licens: CC BY
10.1136/bmj.j3168Licens: CC BY-NC

Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settingsForlagets udgivne version, 1,18 MBLicens: CC BY

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Hopkins, H., Bruxvoort, K. J., Cairns, M. E., Chandler, C. I. R., Leurent, B., Ansah, E. K., Baiden, F., Baltzell, K. A., Björkman, A., Burchett, H. E. D., Clarke, S. E., DiLiberto, D. D., Elfving, K., Goodman, C., Hansen, K. S., Kachur, S. P., Lal, S., Lalloo, D. G., Leslie, T., ... Whitty, C. J. M. (2017). Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings. The BMJ, 356, Artikel j1054. https://doi.org/10.1136/bmj.j1054, https://doi.org/10.1136/bmj.j3168

Hopkins, H, Bruxvoort, KJ, Cairns, ME, Chandler, CIR, Leurent, B, Ansah, EK, Baiden, F, Baltzell, KA, Björkman, A, Burchett, HED, Clarke, SE, DiLiberto, DD, Elfving, K, Goodman, C, Hansen, KS, Kachur, SP, Lal, S, Lalloo, DG, Leslie, T, Magnussen, P, Jefferies, LM, Mårtensson, A, Mayan, I, Mbonye, AK, Msellem, MI, Onwujekwe, OE, Owusu-Agyei, S, Reyburn, H, Rowland, MW, Shakely, D, Vestergaard, LS, Webster, J, Wiseman, VL, Yeung, S, Schellenberg, D, Staedke, SG & Whitty, CJM 2017, 'Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings', The BMJ, bind 356, j1054. https://doi.org/10.1136/bmj.j1054, https://doi.org/10.1136/bmj.j3168

@article{62695cb485a745d8aa8e325602fac009,

title = "Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings",

abstract = "Objectives To examine the impact of use of rapid diagnostic tests for malaria on prescribing of antimicrobials, specifically antibiotics, for acute febrile illness in Africa and Asia.Design Analysisof nine preselected linked and codesigned observational and randomised studies (eight cluster or individually randomised trials and one observational study).Setting Public and private healthcare settings, 2007-13, in Afghanistan, Cameroon, Ghana, Nigeria, Tanzania, and Uganda.Participants 522 480 children and adults with acute febrile illness.Interventions Rapid diagnostic tests for malaria.Main outcome measures Proportions of patients for whom an antibiotic was prescribed in trial groups who had undergone rapid diagnostic testing compared with controls and in patients with negative test results compared with patients with positive results. A secondary aim compared classes of antibiotics prescribed in different settings.Results Antibiotics were prescribed to 127 052/238 797 (53%) patients in control groups and 167 714/283 683 (59%) patients in intervention groups. Antibiotics were prescribed to 40% (35 505/89 719) of patients with a positive test result for malaria and to 69% (39 400/57 080) of those with a negative result. All but one study showed a trend toward more antibiotic prescribing in groups who underwent rapid diagnostic tests. Random effects meta-analysis of the trials showed that the overall risk of antibiotic prescription was 21% higher (95% confidence interval 7% to 36%) in intervention settings. In most intervention settings, patients with negative test results received more antibiotic prescriptions than patients with positive results for all the most commonly used classes: penicillins, trimethoprim-sulfamethoxazole (one exception), tetracyclines, and metronidazole.Conclusions Introduction of rapid diagnostic tests for malaria to reduce unnecessary use of antimalarials-a beneficial public health outcome-could drive up untargeted use of antibiotics. That 69% of patients were prescribed antibiotics when test results were negative probably represents overprescription.This included antibiotics from several classes, including those like metronidazole that are seldom appropriate for febrile illness, across varied clinical, health system, and epidemiological settings. It is often assumed that better disease specific diagnostics will reduce antimicrobial overuse, but they might simply shift it from one antimicrobial class to another. Current global implementation of malaria testing might increase untargeted antibiotic use and must be examined.",

author = "Heidi Hopkins and Bruxvoort, {Katia J} and Cairns, {Matthew E} and Chandler, {Clare I R} and Baptiste Leurent and Ansah, {Evelyn K} and Frank Baiden and Baltzell, {Kimberly A} and Anders Bj{\"o}rkman and Burchett, {Helen E D} and Clarke, {Si{\^a}n E} and DiLiberto, {Deborah D} and Kristina Elfving and Catherine Goodman and Hansen, {Kristian S} and Kachur, {S Patrick} and Sham Lal and Lalloo, {David G} and Toby Leslie and Pascal Magnussen and Jefferies, {Lindsay Mangham} and Andreas M{\aa}rtensson and Ismail Mayan and Mbonye, {Anthony K} and Msellem, {Mwinyi I} and Onwujekwe, {Obinna E} and Seth Owusu-Agyei and Hugh Reyburn and Rowland, {Mark W} and Del{\'e}r Shakely and Vestergaard, {Lasse S} and Jayne Webster and Wiseman, {Virginia L} and Shunmay Yeung and David Schellenberg and Staedke, {Sarah G} and Whitty, {Christopher J M}",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2017",

doi = "10.1136/bmj.j1054",

language = "English",

volume = "356",

journal = "The BMJ",

issn = "0959-8146",

publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing

T2 - analysis of observational and randomised studies in public and private healthcare settings

AU - Hopkins, Heidi

AU - Bruxvoort, Katia J

AU - Cairns, Matthew E

AU - Chandler, Clare I R

AU - Leurent, Baptiste

AU - Ansah, Evelyn K

AU - Baiden, Frank

AU - Baltzell, Kimberly A

AU - Björkman, Anders

AU - Burchett, Helen E D

AU - Clarke, Siân E

AU - DiLiberto, Deborah D

AU - Elfving, Kristina

AU - Goodman, Catherine

AU - Hansen, Kristian S

AU - Kachur, S Patrick

AU - Lal, Sham

AU - Lalloo, David G

AU - Leslie, Toby

AU - Magnussen, Pascal

AU - Jefferies, Lindsay Mangham

AU - Mårtensson, Andreas

AU - Mayan, Ismail

AU - Mbonye, Anthony K

AU - Msellem, Mwinyi I

AU - Onwujekwe, Obinna E

AU - Owusu-Agyei, Seth

AU - Reyburn, Hugh

AU - Rowland, Mark W

AU - Shakely, Delér

AU - Vestergaard, Lasse S

AU - Webster, Jayne

AU - Wiseman, Virginia L

AU - Yeung, Shunmay

AU - Schellenberg, David

AU - Staedke, Sarah G

AU - Whitty, Christopher J M

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2017

Y1 - 2017

N2 - Objectives To examine the impact of use of rapid diagnostic tests for malaria on prescribing of antimicrobials, specifically antibiotics, for acute febrile illness in Africa and Asia.Design Analysisof nine preselected linked and codesigned observational and randomised studies (eight cluster or individually randomised trials and one observational study).Setting Public and private healthcare settings, 2007-13, in Afghanistan, Cameroon, Ghana, Nigeria, Tanzania, and Uganda.Participants 522 480 children and adults with acute febrile illness.Interventions Rapid diagnostic tests for malaria.Main outcome measures Proportions of patients for whom an antibiotic was prescribed in trial groups who had undergone rapid diagnostic testing compared with controls and in patients with negative test results compared with patients with positive results. A secondary aim compared classes of antibiotics prescribed in different settings.Results Antibiotics were prescribed to 127 052/238 797 (53%) patients in control groups and 167 714/283 683 (59%) patients in intervention groups. Antibiotics were prescribed to 40% (35 505/89 719) of patients with a positive test result for malaria and to 69% (39 400/57 080) of those with a negative result. All but one study showed a trend toward more antibiotic prescribing in groups who underwent rapid diagnostic tests. Random effects meta-analysis of the trials showed that the overall risk of antibiotic prescription was 21% higher (95% confidence interval 7% to 36%) in intervention settings. In most intervention settings, patients with negative test results received more antibiotic prescriptions than patients with positive results for all the most commonly used classes: penicillins, trimethoprim-sulfamethoxazole (one exception), tetracyclines, and metronidazole.Conclusions Introduction of rapid diagnostic tests for malaria to reduce unnecessary use of antimalarials-a beneficial public health outcome-could drive up untargeted use of antibiotics. That 69% of patients were prescribed antibiotics when test results were negative probably represents overprescription.This included antibiotics from several classes, including those like metronidazole that are seldom appropriate for febrile illness, across varied clinical, health system, and epidemiological settings. It is often assumed that better disease specific diagnostics will reduce antimicrobial overuse, but they might simply shift it from one antimicrobial class to another. Current global implementation of malaria testing might increase untargeted antibiotic use and must be examined.

AB - Objectives To examine the impact of use of rapid diagnostic tests for malaria on prescribing of antimicrobials, specifically antibiotics, for acute febrile illness in Africa and Asia.Design Analysisof nine preselected linked and codesigned observational and randomised studies (eight cluster or individually randomised trials and one observational study).Setting Public and private healthcare settings, 2007-13, in Afghanistan, Cameroon, Ghana, Nigeria, Tanzania, and Uganda.Participants 522 480 children and adults with acute febrile illness.Interventions Rapid diagnostic tests for malaria.Main outcome measures Proportions of patients for whom an antibiotic was prescribed in trial groups who had undergone rapid diagnostic testing compared with controls and in patients with negative test results compared with patients with positive results. A secondary aim compared classes of antibiotics prescribed in different settings.Results Antibiotics were prescribed to 127 052/238 797 (53%) patients in control groups and 167 714/283 683 (59%) patients in intervention groups. Antibiotics were prescribed to 40% (35 505/89 719) of patients with a positive test result for malaria and to 69% (39 400/57 080) of those with a negative result. All but one study showed a trend toward more antibiotic prescribing in groups who underwent rapid diagnostic tests. Random effects meta-analysis of the trials showed that the overall risk of antibiotic prescription was 21% higher (95% confidence interval 7% to 36%) in intervention settings. In most intervention settings, patients with negative test results received more antibiotic prescriptions than patients with positive results for all the most commonly used classes: penicillins, trimethoprim-sulfamethoxazole (one exception), tetracyclines, and metronidazole.Conclusions Introduction of rapid diagnostic tests for malaria to reduce unnecessary use of antimalarials-a beneficial public health outcome-could drive up untargeted use of antibiotics. That 69% of patients were prescribed antibiotics when test results were negative probably represents overprescription.This included antibiotics from several classes, including those like metronidazole that are seldom appropriate for febrile illness, across varied clinical, health system, and epidemiological settings. It is often assumed that better disease specific diagnostics will reduce antimicrobial overuse, but they might simply shift it from one antimicrobial class to another. Current global implementation of malaria testing might increase untargeted antibiotic use and must be examined.

U2 - 10.1136/bmj.j1054

DO - 10.1136/bmj.j1054

M3 - Journal article

C2 - 28356302

SN - 0959-8146

VL - 356

JO - The BMJ

JF - The BMJ

M1 - j1054

ER -

Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings

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