Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes

Kamlesh Khunti; Saud Alsifri; Ronnie Aronson; Maja Cigrovski Berković; Catherine Enters-Weijnen; Tom Forsén; Gagik Galstyan; Petronella Geelhoed-Duijvestijn; Margalit Goldfracht; Helge Gydesen; Rahul Kapur; Nebojsa Lalic; Bernhard Ludvik; Erik Moberg; Ulrik Pedersen-Bjergaard; Ambady Ramachandran; HAT Investigator Group

doi:10.1016/j.diabres.2017.05.004

Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes

Kamlesh Khunti, Saud Alsifri, Ronnie Aronson, Maja Cigrovski Berković, Catherine Enters-Weijnen, Tom Forsén, Gagik Galstyan, Petronella Geelhoed-Duijvestijn, Margalit Goldfracht, Helge Gydesen, Rahul Kapur, Nebojsa Lalic, Bernhard Ludvik, Erik Moberg, Ulrik Pedersen-Bjergaard, Ambady Ramachandran, HAT Investigator Group

Institut for Klinisk Medicin

29 Citationer (Scopus)

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Abstract

AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally.

MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide.

RESULTS: Increased blood glucose monitoring (69.7%) and seeking medical assistance (62.0%) were the most common responses in the 4weeks following hypoglycaemic events for patients with type 1 diabetes and type 2 diabetes, respectively. Approximately 44% of patients with type 1 diabetes or type 2 diabetes increased calorie intake in response to a hypoglycaemic episode. Following hypoglycaemia, 3.9% (type 1 diabetes) and 6.2% (type 2 diabetes) of patients took leave from work or study. Regional differences in fear of, and responses to, hypoglycaemia were evident - in particular, a lower level of hypoglycaemic fear and utilisation of healthcare resources in Northern Europe and Canada.

CONCLUSIONS: Hypoglycaemia has a major impact on patients and their behaviour. These global data for the first time reveal regional variations in response to hypoglycaemia and highlight the importance of patient education and management strategies.

Originalsprog	Engelsk
Tidsskrift	Diabetes Research and Clinical Practice
Vol/bind	130
Sider (fra-til)	121-129
ISSN	0168-8227
DOI	https://doi.org/10.1016/j.diabres.2017.05.004
Status	Udgivet - aug. 2017

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10.1016/j.diabres.2017.05.004Licens: CC BY-NC-ND

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Khunti, K., Alsifri, S., Aronson, R., Cigrovski Berković, M., Enters-Weijnen, C., Forsén, T., Galstyan, G., Geelhoed-Duijvestijn, P., Goldfracht, M., Gydesen, H., Kapur, R., Lalic, N., Ludvik, B., Moberg, E., Pedersen-Bjergaard, U., Ramachandran, A., & HAT Investigator Group (2017). Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes. Diabetes Research and Clinical Practice, 130, 121-129. https://doi.org/10.1016/j.diabres.2017.05.004

Khunti, K, Alsifri, S, Aronson, R, Cigrovski Berković, M, Enters-Weijnen, C, Forsén, T, Galstyan, G, Geelhoed-Duijvestijn, P, Goldfracht, M, Gydesen, H, Kapur, R, Lalic, N, Ludvik, B, Moberg, E, Pedersen-Bjergaard, U, Ramachandran, A & HAT Investigator Group 2017, 'Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes', Diabetes Research and Clinical Practice, bind 130, s. 121-129. https://doi.org/10.1016/j.diabres.2017.05.004

@article{0142bb8c952740f4ad8064bf560add96,

title = "Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes",

abstract = "AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally.MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide.RESULTS: Increased blood glucose monitoring (69.7%) and seeking medical assistance (62.0%) were the most common responses in the 4weeks following hypoglycaemic events for patients with type 1 diabetes and type 2 diabetes, respectively. Approximately 44% of patients with type 1 diabetes or type 2 diabetes increased calorie intake in response to a hypoglycaemic episode. Following hypoglycaemia, 3.9% (type 1 diabetes) and 6.2% (type 2 diabetes) of patients took leave from work or study. Regional differences in fear of, and responses to, hypoglycaemia were evident - in particular, a lower level of hypoglycaemic fear and utilisation of healthcare resources in Northern Europe and Canada.CONCLUSIONS: Hypoglycaemia has a major impact on patients and their behaviour. These global data for the first time reveal regional variations in response to hypoglycaemia and highlight the importance of patient education and management strategies.",

keywords = "Adult, Canada, Diabetes Mellitus, Type 1/complications, Diabetes Mellitus, Type 2/complications, Europe, Fear, Female, Humans, Hypoglycemia/chemically induced, Hypoglycemic Agents/therapeutic use, Insulin/adverse effects, Male, Middle Aged, Patient Education as Topic, Patient Reported Outcome Measures, Prospective Studies, Self-Management, Surveys and Questionnaires",

author = "Kamlesh Khunti and Saud Alsifri and Ronnie Aronson and {Cigrovski Berkovi{\'c}}, Maja and Catherine Enters-Weijnen and Tom Fors{\'e}n and Gagik Galstyan and Petronella Geelhoed-Duijvestijn and Margalit Goldfracht and Helge Gydesen and Rahul Kapur and Nebojsa Lalic and Bernhard Ludvik and Erik Moberg and Ulrik Pedersen-Bjergaard and Ambady Ramachandran and {HAT Investigator Group}",

year = "2017",

month = aug,

doi = "10.1016/j.diabres.2017.05.004",

language = "English",

volume = "130",

pages = "121--129",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes

AU - Khunti, Kamlesh

AU - Alsifri, Saud

AU - Aronson, Ronnie

AU - Cigrovski Berković, Maja

AU - Enters-Weijnen, Catherine

AU - Forsén, Tom

AU - Galstyan, Gagik

AU - Geelhoed-Duijvestijn, Petronella

AU - Goldfracht, Margalit

AU - Gydesen, Helge

AU - Kapur, Rahul

AU - Lalic, Nebojsa

AU - Ludvik, Bernhard

AU - Moberg, Erik

AU - Pedersen-Bjergaard, Ulrik

AU - Ramachandran, Ambady

AU - HAT Investigator Group

PY - 2017/8

Y1 - 2017/8

N2 - AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally.MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide.RESULTS: Increased blood glucose monitoring (69.7%) and seeking medical assistance (62.0%) were the most common responses in the 4weeks following hypoglycaemic events for patients with type 1 diabetes and type 2 diabetes, respectively. Approximately 44% of patients with type 1 diabetes or type 2 diabetes increased calorie intake in response to a hypoglycaemic episode. Following hypoglycaemia, 3.9% (type 1 diabetes) and 6.2% (type 2 diabetes) of patients took leave from work or study. Regional differences in fear of, and responses to, hypoglycaemia were evident - in particular, a lower level of hypoglycaemic fear and utilisation of healthcare resources in Northern Europe and Canada.CONCLUSIONS: Hypoglycaemia has a major impact on patients and their behaviour. These global data for the first time reveal regional variations in response to hypoglycaemia and highlight the importance of patient education and management strategies.

AB - AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally.MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide.RESULTS: Increased blood glucose monitoring (69.7%) and seeking medical assistance (62.0%) were the most common responses in the 4weeks following hypoglycaemic events for patients with type 1 diabetes and type 2 diabetes, respectively. Approximately 44% of patients with type 1 diabetes or type 2 diabetes increased calorie intake in response to a hypoglycaemic episode. Following hypoglycaemia, 3.9% (type 1 diabetes) and 6.2% (type 2 diabetes) of patients took leave from work or study. Regional differences in fear of, and responses to, hypoglycaemia were evident - in particular, a lower level of hypoglycaemic fear and utilisation of healthcare resources in Northern Europe and Canada.CONCLUSIONS: Hypoglycaemia has a major impact on patients and their behaviour. These global data for the first time reveal regional variations in response to hypoglycaemia and highlight the importance of patient education and management strategies.

KW - Adult

KW - Canada

KW - Diabetes Mellitus, Type 1/complications

KW - Diabetes Mellitus, Type 2/complications

KW - Europe

KW - Fear

KW - Female

KW - Humans

KW - Hypoglycemia/chemically induced

KW - Hypoglycemic Agents/therapeutic use

KW - Insulin/adverse effects

KW - Male

KW - Middle Aged

KW - Patient Education as Topic

KW - Patient Reported Outcome Measures

KW - Prospective Studies

KW - Self-Management

KW - Surveys and Questionnaires

U2 - 10.1016/j.diabres.2017.05.004

DO - 10.1016/j.diabres.2017.05.004

M3 - Journal article

C2 - 28602812

SN - 0168-8227

VL - 130

SP - 121

EP - 129

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

ER -

Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes

Abstract

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