Impact of a Graded Exercise Program on V˙O2peak and Survival in Heart Failure Patients

TY - JOUR

T1 - Impact of a Graded Exercise Program on V˙O2peak and Survival in Heart Failure Patients

AU - Snoek, Johan A

AU - Eijsvogels, Thijs M H

AU - VAN 't Hof, Arnoud W J

AU - Prescott, Eva

AU - Hopman, Maria T

AU - Kolkman, Evelien

AU - DE Kluiver, E D P

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Introduction Although exercise therapy has the potential to improve health outcomes of patients with chronic heart failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines 1 yr after cardiac rehabilitation. We aimed to assess the effects of an extended cardiac rehabilitation program with 12 months of graded exercise therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. Methods This prospective cohort study included 60 CHF patients between 2009 and 2010. The GET-RT program consisted of exercise sessions at 6 d·wk -1. Total training time of aerobic exercises increased incrementally every other week without changing exercise intensity. Resistance exercise training consisted of 8 exercises with a durable resistance band. Guidance consisted of a step-down approach from in-hospital to home-based training. Cardiopulmonary exercise tests were performed at baseline, 3, 6, and 12 months. Subsequently, patients were propensity score matched on a 1:2 ratio with controls (n = 117) from a CHF registry of patients from the same clinic receiving usual out-patient care and the incidence of all-cause mortality was compared between both groups. Results Baseline V-O 2 peak was 15.0 mL·min -1 ·kg -1 and significantly elevated at 3 months (+1.1 mL·min -1 ·kg -1 (95% CI, 0.4-1.8), 6 months (+2.9 mL·min -1 ·kg -1 (95% CI, 1.1-2.9) and 12 months (+2.6 mL·min -1 ·kg -1 (95% CI, 1.4-3.8). During 8 yr of follow-up 23 (38.3%) patients of the GET-RT program died versus 63 (53.8%) patients of the control group (P = 0.063). Conclusions The 12-month GET-RT program was associated with an improved fitness during 1-yr follow-up, whereas a tendency toward better survival rates was observed during long-term follow-up.

AB - Introduction Although exercise therapy has the potential to improve health outcomes of patients with chronic heart failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines 1 yr after cardiac rehabilitation. We aimed to assess the effects of an extended cardiac rehabilitation program with 12 months of graded exercise therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. Methods This prospective cohort study included 60 CHF patients between 2009 and 2010. The GET-RT program consisted of exercise sessions at 6 d·wk -1. Total training time of aerobic exercises increased incrementally every other week without changing exercise intensity. Resistance exercise training consisted of 8 exercises with a durable resistance band. Guidance consisted of a step-down approach from in-hospital to home-based training. Cardiopulmonary exercise tests were performed at baseline, 3, 6, and 12 months. Subsequently, patients were propensity score matched on a 1:2 ratio with controls (n = 117) from a CHF registry of patients from the same clinic receiving usual out-patient care and the incidence of all-cause mortality was compared between both groups. Results Baseline V-O 2 peak was 15.0 mL·min -1 ·kg -1 and significantly elevated at 3 months (+1.1 mL·min -1 ·kg -1 (95% CI, 0.4-1.8), 6 months (+2.9 mL·min -1 ·kg -1 (95% CI, 1.1-2.9) and 12 months (+2.6 mL·min -1 ·kg -1 (95% CI, 1.4-3.8). During 8 yr of follow-up 23 (38.3%) patients of the GET-RT program died versus 63 (53.8%) patients of the control group (P = 0.063). Conclusions The 12-month GET-RT program was associated with an improved fitness during 1-yr follow-up, whereas a tendency toward better survival rates was observed during long-term follow-up.

KW - Aged

KW - Cardiorespiratory Fitness

KW - Exercise Test

KW - Exercise Therapy/methods

KW - Female

KW - Follow-Up Studies

KW - Heart Failure/metabolism

KW - Humans

KW - Male

KW - Middle Aged

KW - Oxygen Consumption

KW - Propensity Score

KW - Prospective Studies

KW - Resistance Training

U2 - 10.1249/mss.0000000000001688

DO - 10.1249/mss.0000000000001688

M3 - Journal article

C2 - 29933343

SN - 0195-9131

VL - 50

SP - 2185

EP - 2191

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 11

ER -