Immunterapi mod Alzheimers sygdom

Alexander Christian Falkentoft; Steen Gregers Hasselbalch

Immunterapi mod Alzheimers sygdom

Alexander Christian Falkentoft, Steen Gregers Hasselbalch

Institut for Klinisk Medicin

1 Citationer (Scopus)

Abstract

Passive anti-beta-amyloid (Aß) immunotherapy has been shown to clear brain Aß deposits. Results from phase III clinical trials in mild-to-moderate Alzheimer's disease (AD) patients with two monoclonal antibodies bapineuzumab and solanezumab and intravenous immunoglobulin have been disappointing. Subsequent analysis of pooled data from both phase III trials with solanezumab showed a reduction in cognitive decline in patients with mild AD. Solanezumab and new monoclonal antibodies are being tested in patients with prodromal and preclinical AD in search for a disease-modifying treatment.

Bidragets oversatte titel	Immunotherapy for Alzheimer's disease
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	178
Udgave nummer	3
Sider (fra-til)	2-6
Antal sider	5
ISSN	0041-5782
Status	Udgivet - 18 jan. 2016

Citationsformater

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Immunterapi mod Alzheimers sygdom

Abstract

Fingeraftryk

Citationsformater