Immunologic Abnormalities, Treatments, and Recurrent Pregnancy Loss: What Is Real and What Is Not?

TY - JOUR

T1 - Immunologic Abnormalities, Treatments, and Recurrent Pregnancy Loss

T2 - What Is Real and What Is Not?

AU - Wang, Nathalie F

AU - Kolte, Astrid M

AU - Larsen, Elisabeth C

AU - Nielsen, Henriette S

AU - Christiansen, Ole B

PY - 2016/7/26

Y1 - 2016/7/26

N2 - Recurrent pregnancy loss, depending on the definition, affects 1% to 3% of women aiming to have a child. Little is known about the direct causes of recurrent pregnancy loss, and the condition is considered to have a multifactorial and complex pathogenesis. The aim of this review was to summarize the evaluation and the management of the condition with specific emphasis on immunologic biomarkers identified as risk factors as well as current immunologic treatment options. The review also highlights and discusses areas in need of further research.

AB - Recurrent pregnancy loss, depending on the definition, affects 1% to 3% of women aiming to have a child. Little is known about the direct causes of recurrent pregnancy loss, and the condition is considered to have a multifactorial and complex pathogenesis. The aim of this review was to summarize the evaluation and the management of the condition with specific emphasis on immunologic biomarkers identified as risk factors as well as current immunologic treatment options. The review also highlights and discusses areas in need of further research.

KW - Journal Article

U2 - 10.1097/GRF.0000000000000215

DO - 10.1097/GRF.0000000000000215

M3 - Review

C2 - 27380207

SN - 0009-9201

VL - 59

SP - 509

EP - 523

JO - Clinical Obstetrics and Gynecology

JF - Clinical Obstetrics and Gynecology

IS - 3

ER -