Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease

E M Vestergaard; J Brynskov; K Ejskjaer; J T Clausen; L Thim; Ebba Nexø; Steen Seier Poulsen

Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease

E M Vestergaard, J Brynskov, K Ejskjaer, J T Clausen, L Thim, Ebba Nexø, Steen Seier Poulsen

Endocrinology and Metabolism

46 Citationer (Scopus)

Abstract

The trefoil factors (TFF1-3) are cysteine-rich peptides expressed in the gastrointestinal tract where they play a critical role in mucosal protection and repair. The expression is up-regulated at sites of ulceration in various chronic inflammatory diseases. Recently, we presented an ELISA method for measurement of TFF3. The aims of the present study were to develop and evaluate ELISAs for the other two known human trefoil peptides, TFF1 and TFF2, and to carry out a cross-sectional study on serum TFF levels in patients with inflammatory bowel disease (IBD).

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Clinical & Laboratory Investigation
Vol/bind	64
Udgave nummer	2
Sider (fra-til)	146-56
Antal sider	11
ISSN	0036-5513
Status	Udgivet - apr. 2004

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Citationsformater

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title = "Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease",

abstract = "The trefoil factors (TFF1-3) are cysteine-rich peptides expressed in the gastrointestinal tract where they play a critical role in mucosal protection and repair. The expression is up-regulated at sites of ulceration in various chronic inflammatory diseases. Recently, we presented an ELISA method for measurement of TFF3. The aims of the present study were to develop and evaluate ELISAs for the other two known human trefoil peptides, TFF1 and TFF2, and to carry out a cross-sectional study on serum TFF levels in patients with inflammatory bowel disease (IBD).",

keywords = "Adolescent, Adult, Aged, Aging, Enzyme-Linked Immunosorbent Assay, Female, Health, Humans, Immunoassay, Inflammatory Bowel Diseases, Male, Middle Aged, Mucins, Muscle Proteins, Peptides, Proteins, Sensitivity and Specificity, Tumor Suppressor Proteins",

author = "Vestergaard, {E M} and J Brynskov and K Ejskjaer and Clausen, {J T} and L Thim and Ebba Nex{\o} and Poulsen, {Steen Seier}",

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month = apr,

language = "English",

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pages = "146--56",

journal = "Scandinavian Journal of Clinical & Laboratory Investigation",

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TY - JOUR

T1 - Immunoassays of human trefoil factors 1 and 2

T2 - measured on serum from patients with inflammatory bowel disease

AU - Vestergaard, E M

AU - Brynskov, J

AU - Ejskjaer, K

AU - Clausen, J T

AU - Thim, L

AU - Nexø, Ebba

AU - Poulsen, Steen Seier

PY - 2004/4

Y1 - 2004/4

N2 - The trefoil factors (TFF1-3) are cysteine-rich peptides expressed in the gastrointestinal tract where they play a critical role in mucosal protection and repair. The expression is up-regulated at sites of ulceration in various chronic inflammatory diseases. Recently, we presented an ELISA method for measurement of TFF3. The aims of the present study were to develop and evaluate ELISAs for the other two known human trefoil peptides, TFF1 and TFF2, and to carry out a cross-sectional study on serum TFF levels in patients with inflammatory bowel disease (IBD).

AB - The trefoil factors (TFF1-3) are cysteine-rich peptides expressed in the gastrointestinal tract where they play a critical role in mucosal protection and repair. The expression is up-regulated at sites of ulceration in various chronic inflammatory diseases. Recently, we presented an ELISA method for measurement of TFF3. The aims of the present study were to develop and evaluate ELISAs for the other two known human trefoil peptides, TFF1 and TFF2, and to carry out a cross-sectional study on serum TFF levels in patients with inflammatory bowel disease (IBD).

KW - Adolescent

KW - Adult

KW - Aged

KW - Aging

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Health

KW - Humans

KW - Immunoassay

KW - Inflammatory Bowel Diseases

KW - Male

KW - Middle Aged

KW - Mucins

KW - Muscle Proteins

KW - Peptides

KW - Proteins

KW - Sensitivity and Specificity

KW - Tumor Suppressor Proteins

M3 - Journal article

C2 - 15115253

SN - 0036-5513

VL - 64

SP - 146

EP - 156

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

IS - 2

ER -

Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease

Abstract

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