Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature

TY - JOUR

T1 - Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas

T2 - Review of the literature

AU - Saber, Camelia Nami

AU - Grønhøj Larsen, Christian

AU - Dalianis, Tina

AU - Von Buchwald, Christian

PY - 2016/7

Y1 - 2016/7

N2 - Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.

AB - Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.

KW - HPV

KW - Immunology

KW - Oropharyngeal tumor

U2 - 10.1016/j.oraloncology.2016.04.004

DO - 10.1016/j.oraloncology.2016.04.004

M3 - Review

C2 - 27311396

AN - SCOPUS:84965102773

SN - 1368-8375

VL - 58

SP - 8

EP - 13

JO - Oral Oncology

JF - Oral Oncology

ER -