IGF-I and IGFBP-3 in healthy 9 month old infants from the SKOT cohort: breastfeeding, diet, and later obesity

TY - JOUR

T1 - IGF-I and IGFBP-3 in healthy 9 month old infants from the SKOT cohort

T2 - breastfeeding, diet, and later obesity

AU - Madsen, Anja Lykke

AU - Larnkjær, Anni

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

PY - 2011/8

Y1 - 2011/8

N2 - Background: High IGF-I concentrations in infancy have been associated with later obesity but the interactions between diet, IGF-I concentrations and growth in early life are complex and involve programming of the IGF-I axis. Objective: This paper examines how IGF-I and IGFBP-3 concentrations measured at age 9. months are related to diet and growth in infancy. Design: In the Danish SKOT cohort healthy term infants were included at age 9. months with follow-up at age 18. months. Total 252 infants had a full data set and were included in the analysis. Measurements include weight, length, skinfold thickness, waist circumference, 7-d food records, and blood analysis of IGF-I, and IGFBP-3. Results: Infants not being breastfed at 9. months of age (46%) had higher median IGF-I concentration than breastfed infants (51.6 vs. 44.2. ng/mL, P= 0.0005) and there was a negative dose response effect of daily numbers of breastfeedings on IGF-I concentration. IGF-I concentration was negatively associated with birth weight and positively related to increase in weight, length and BMI between birth and 9. months. Between 9. months and 18. months of age increase in length was positively and increase in BMI was negatively related to IGF-I concentration. Conclusion: Breastfeeding has a strong negative effect on IGF-I concentrations in late infancy. Although IGF-I concentrations at 9. months of age were negatively associated with change in BMI during the following 9. months we speculate that this could reflect an early adiposity rebound and thereby an increased risk of obesity later in life.

AB - Background: High IGF-I concentrations in infancy have been associated with later obesity but the interactions between diet, IGF-I concentrations and growth in early life are complex and involve programming of the IGF-I axis. Objective: This paper examines how IGF-I and IGFBP-3 concentrations measured at age 9. months are related to diet and growth in infancy. Design: In the Danish SKOT cohort healthy term infants were included at age 9. months with follow-up at age 18. months. Total 252 infants had a full data set and were included in the analysis. Measurements include weight, length, skinfold thickness, waist circumference, 7-d food records, and blood analysis of IGF-I, and IGFBP-3. Results: Infants not being breastfed at 9. months of age (46%) had higher median IGF-I concentration than breastfed infants (51.6 vs. 44.2. ng/mL, P= 0.0005) and there was a negative dose response effect of daily numbers of breastfeedings on IGF-I concentration. IGF-I concentration was negatively associated with birth weight and positively related to increase in weight, length and BMI between birth and 9. months. Between 9. months and 18. months of age increase in length was positively and increase in BMI was negatively related to IGF-I concentration. Conclusion: Breastfeeding has a strong negative effect on IGF-I concentrations in late infancy. Although IGF-I concentrations at 9. months of age were negatively associated with change in BMI during the following 9. months we speculate that this could reflect an early adiposity rebound and thereby an increased risk of obesity later in life.

U2 - 10.1016/j.ghir.2011.05.003

DO - 10.1016/j.ghir.2011.05.003

M3 - Journal article

C2 - 21624842

SN - 1096-6374

VL - 21

SP - 199

EP - 204

JO - Growth Hormone & IGF Research

JF - Growth Hormone & IGF Research

IS - 4

ER -