TY - JOUR
T1 - Identifying Life-Threatening Admissions for Drug Dependence or Abuse (ILIADDA)
T2 - Derivation and Validation of a Model.
AU - Nguyen, Tri Long
AU - Boudemaghe, Thierry
AU - Leguelinel-Blache, Géraldine
AU - Eiden, Céline
AU - Kinowski, Jean Marie
AU - Le Manach, Yannick
AU - Peyrière, Hélène
AU - Landais, Paul
PY - 2017
Y1 - 2017
N2 - Given that drug abuse and dependence are common reasons for hospitalization, we aimed to derive and validate a model allowing early identification of life-Threatening hospital admissions for drug dependence or abuse. Using the French National Hospital Discharge Data Base, we extracted 66,101 acute inpatient stays for substance abuse, dependence, mental disorders or poisoning associated with medicines or illicit drugs intake, recorded between January 1 st, 2009 and December 31 st, 2014. We split our study cohort at the center level to create a derivation cohort and a validation cohort. We developed a multivariate logistic model including patient's age, sex, entrance mode and diagnosis as predictors of a composite primary outcome of in-hospital death or ICU admission. A total of 2,747 (4.2%) patients died or were admitted to ICU. The risk of death or ICU admission was mainly associated with the consumption of opioids, followed by cocaine and other narcotics. Particularly, methadone poisoning was associated with a substantial risk (OR: 35.70, 95% CI [26.94-47.32], P < 0.001). In the validation cohort, our model achieved good predictive properties in terms of calibration and discrimination (c-statistic: 0.847). This allows an accurate identification of life-Threatening admissions in drug users to support an early and appropriate management.
AB - Given that drug abuse and dependence are common reasons for hospitalization, we aimed to derive and validate a model allowing early identification of life-Threatening hospital admissions for drug dependence or abuse. Using the French National Hospital Discharge Data Base, we extracted 66,101 acute inpatient stays for substance abuse, dependence, mental disorders or poisoning associated with medicines or illicit drugs intake, recorded between January 1 st, 2009 and December 31 st, 2014. We split our study cohort at the center level to create a derivation cohort and a validation cohort. We developed a multivariate logistic model including patient's age, sex, entrance mode and diagnosis as predictors of a composite primary outcome of in-hospital death or ICU admission. A total of 2,747 (4.2%) patients died or were admitted to ICU. The risk of death or ICU admission was mainly associated with the consumption of opioids, followed by cocaine and other narcotics. Particularly, methadone poisoning was associated with a substantial risk (OR: 35.70, 95% CI [26.94-47.32], P < 0.001). In the validation cohort, our model achieved good predictive properties in terms of calibration and discrimination (c-statistic: 0.847). This allows an accurate identification of life-Threatening admissions in drug users to support an early and appropriate management.
U2 - 10.1038/srep44428
DO - 10.1038/srep44428
M3 - Journal article
C2 - 28290530
AN - SCOPUS:85015301111
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
M1 - 44428
ER -
