Identification of monoclinic calcium pyrophosphate dihydrate and hydroxyapatite in human sclera using Raman microspectroscopy

Ko-Hua Chen; Mei-Jane Li; Wen-Ting Cheng; Tonci Balic Zunic; Shan-Yang Lin

doi:10.1111/j.1365-2613.2008.00614.x

Identification of monoclinic calcium pyrophosphate dihydrate and hydroxyapatite in human sclera using Raman microspectroscopy

Ko-Hua Chen, Mei-Jane Li, Wen-Ting Cheng, Tonci Balic Zunic, Shan-Yang Lin

Geologi

24 Citationer (Scopus)

Abstract

Raman microspectroscopy was first used to determine the composition of a calcified plaque located at the pterygium-excision site of a 51-year-old female patient's left nasal sclera after surgery. It was unexpectedly found that the Raman spectrum of the calcified sample at 1149, 1108, 1049, 756, 517, 376 and 352/cm was similar to the Raman spectrum of monoclinic form of calcium pyrophosphate dihydrate (CPPD) crystal, but differed from the Raman spectrum of triclinic form of CPPD. An additional peak at 958/cm was also observed in the Raman spectrum of the calcified plaque, which was identical to the characteristic peak at 958/cm of hydroxyapatite (HA). This is the first study to report the spectral biodiagnosis of both monoclinic CPPD and HA co-deposited in the calcified plaque of a patient with sclera dystrophic calcification using Raman microspectroscopy.

Originalsprog	Engelsk
Tidsskrift	International Journal of Experimental Pathology
Vol/bind	90
Udgave nummer	1
Sider (fra-til)	74-78
ISSN	0959-9673
DOI	https://doi.org/10.1111/j.1365-2613.2008.00614.x
Status	Udgivet - 2009

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Det Natur- og Biovidenskabelige Fakultet

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10.1111/j.1365-2613.2008.00614.x

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title = "Identification of monoclinic calcium pyrophosphate dihydrate and hydroxyapatite in human sclera using Raman microspectroscopy",

abstract = "Raman microspectroscopy was first used to determine the composition of a calcified plaque located at the pterygium-excision site of a 51-year-old female patient's left nasal sclera after surgery. It was unexpectedly found that the Raman spectrum of the calcified sample at 1149, 1108, 1049, 756, 517, 376 and 352/cm was similar to the Raman spectrum of monoclinic form of calcium pyrophosphate dihydrate (CPPD) crystal, but differed from the Raman spectrum of triclinic form of CPPD. An additional peak at 958/cm was also observed in the Raman spectrum of the calcified plaque, which was identical to the characteristic peak at 958/cm of hydroxyapatite (HA). This is the first study to report the spectral biodiagnosis of both monoclinic CPPD and HA co-deposited in the calcified plaque of a patient with sclera dystrophic calcification using Raman microspectroscopy.",

keywords = "Faculty of Science, calcium pyrophosphate dihydrate, sclera, Raman microspectroscopy, hydroxyapatite, dystrophic calcification",

author = "Ko-Hua Chen and Mei-Jane Li and Wen-Ting Cheng and {Balic Zunic}, Tonci and Shan-Yang Lin",

year = "2009",

doi = "10.1111/j.1365-2613.2008.00614.x",

language = "English",

volume = "90",

pages = "74--78",

journal = "International Journal of Experimental Pathology",

issn = "0959-9673",

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TY - JOUR

T1 - Identification of monoclinic calcium pyrophosphate dihydrate and hydroxyapatite in human sclera using Raman microspectroscopy

AU - Chen, Ko-Hua

AU - Li, Mei-Jane

AU - Cheng, Wen-Ting

AU - Balic Zunic, Tonci

AU - Lin, Shan-Yang

PY - 2009

Y1 - 2009

N2 - Raman microspectroscopy was first used to determine the composition of a calcified plaque located at the pterygium-excision site of a 51-year-old female patient's left nasal sclera after surgery. It was unexpectedly found that the Raman spectrum of the calcified sample at 1149, 1108, 1049, 756, 517, 376 and 352/cm was similar to the Raman spectrum of monoclinic form of calcium pyrophosphate dihydrate (CPPD) crystal, but differed from the Raman spectrum of triclinic form of CPPD. An additional peak at 958/cm was also observed in the Raman spectrum of the calcified plaque, which was identical to the characteristic peak at 958/cm of hydroxyapatite (HA). This is the first study to report the spectral biodiagnosis of both monoclinic CPPD and HA co-deposited in the calcified plaque of a patient with sclera dystrophic calcification using Raman microspectroscopy.

AB - Raman microspectroscopy was first used to determine the composition of a calcified plaque located at the pterygium-excision site of a 51-year-old female patient's left nasal sclera after surgery. It was unexpectedly found that the Raman spectrum of the calcified sample at 1149, 1108, 1049, 756, 517, 376 and 352/cm was similar to the Raman spectrum of monoclinic form of calcium pyrophosphate dihydrate (CPPD) crystal, but differed from the Raman spectrum of triclinic form of CPPD. An additional peak at 958/cm was also observed in the Raman spectrum of the calcified plaque, which was identical to the characteristic peak at 958/cm of hydroxyapatite (HA). This is the first study to report the spectral biodiagnosis of both monoclinic CPPD and HA co-deposited in the calcified plaque of a patient with sclera dystrophic calcification using Raman microspectroscopy.

KW - Faculty of Science

KW - calcium pyrophosphate dihydrate

KW - sclera

KW - Raman microspectroscopy

KW - hydroxyapatite

KW - dystrophic calcification

U2 - 10.1111/j.1365-2613.2008.00614.x

DO - 10.1111/j.1365-2613.2008.00614.x

M3 - Journal article

C2 - 19200254

SN - 0959-9673

VL - 90

SP - 74

EP - 78

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

IS - 1

ER -

Identification of monoclinic calcium pyrophosphate dihydrate and hydroxyapatite in human sclera using Raman microspectroscopy

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