@article{a7fe020b32ca401b94ca4e0292cd6f75,
title = "Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model",
abstract = "The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.",
keywords = "Analysis of Variance, Animals, COS Cells, Cercopithecus aethiops, Cytomegalovirus, HEK293 Cells, Humans, Luciferases, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Octoxynol, Phenotype, Receptors, Chemokine, Receptors, G-Protein-Coupled, Salivary Glands, Signal Transduction, Viral Proteins, Viral Tropism, Virus Activation, Virus Latency",
author = "Farrell, {Helen E} and Abraham, {Alexander M} and Cardin, {Rhonda D} and Ann-Sofie M{\o}lleskov-Jensen and Rosenkilde, {Mette Marie} and Nicholas Davis-Poynter",
year = "2013",
month = apr,
doi = "10.1128/JVI.03406-12",
language = "English",
volume = "87",
pages = "4112--7",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "7",
}