Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A Eeles; Ali Amin Al Olama; Sara Benlloch; Edward J Saunders; Daniel A Leongamornlert; Malgorzata Tymrakiewicz; Maya Ghoussaini; Craig Luccarini; Joe Dennis; Sarah Jugurnauth-Little; Tokhir Dadaev; David E Neal; Freddie C Hamdy; Jenny L Donovan; Ken Muir; Graham G Giles; Gianluca Severi; Fredrik Wiklund; Henrik Gronberg; Christopher A Haiman; Fredrick Schumacher; Brian E Henderson; Loic Le Marchand; Sara Lindstrom; Peter Kraft; David J Hunter; Susan Gapstur; Stephen J Chanock; Sonja I Berndt; Demetrius Albanes; Gerald Andriole; Johanna Schleutker; Maren Weischer; Federico Canzian; Elio Riboli; Tim J Key; Ruth C Travis; Daniele Campa; Sue A Ingles; Esther M John; Richard B Hayes; Paul D P Pharoah; Nora Pashayan; Kay-Tee Khaw; Janet L Stanford; Elaine A Ostrander; Lisa B Signorello; Stephen N Thibodeau; Dan Schaid; Børge G Nordestgaard; The COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative

doi:10.1038/ng.2560

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E Neal, Freddie C Hamdy, Jenny L Donovan, Ken Muir, Graham G Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A HaimanFredrick Schumacher, Brian E Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen J Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J Key, Ruth C Travis, Daniele Campa, Sue A Ingles, Esther M John, Richard B Hayes, Paul D P Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Dan Schaid, Børge G Nordestgaard, The COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative

397 Citationer (Scopus)

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	45
Udgave nummer	4
Sider (fra-til)	385-391
Antal sider	7
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.2560
Status	Udgivet - apr. 2013

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Eeles, R. A., Olama, A. A. A., Benlloch, S., Saunders, E. J., Leongamornlert, D. A., Tymrakiewicz, M., Ghoussaini, M., Luccarini, C., Dennis, J., Jugurnauth-Little, S., Dadaev, T., Neal, D. E., Hamdy, F. C., Donovan, J. L., Muir, K., Giles, G. G., Severi, G., Wiklund, F., Gronberg, H., ... The COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative (2013). Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 45(4), 385-391. https://doi.org/10.1038/ng.2560

Eeles, RA, Olama, AAA, Benlloch, S, Saunders, EJ, Leongamornlert, DA, Tymrakiewicz, M, Ghoussaini, M, Luccarini, C, Dennis, J, Jugurnauth-Little, S, Dadaev, T, Neal, DE, Hamdy, FC, Donovan, JL, Muir, K, Giles, GG, Severi, G, Wiklund, F, Gronberg, H, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Lindstrom, S, Kraft, P, Hunter, DJ, Gapstur, S, Chanock, SJ, Berndt, SI, Albanes, D, Andriole, G, Schleutker, J, Weischer, M, Canzian, F, Riboli, E, Key, TJ, Travis, RC, Campa, D, Ingles, SA, John, EM, Hayes, RB, Pharoah, PDP, Pashayan, N, Khaw, K-T, Stanford, JL, Ostrander, EA, Signorello, LB, Thibodeau, SN, Schaid, D, Nordestgaard, BG & The COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative 2013, 'Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array', Nature Genetics, bind 45, nr. 4, s. 385-391. https://doi.org/10.1038/ng.2560

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title = "Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array",

abstract = "Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.",

author = "Eeles, {Rosalind A} and Olama, {Ali Amin Al} and Sara Benlloch and Saunders, {Edward J} and Leongamornlert, {Daniel A} and Malgorzata Tymrakiewicz and Maya Ghoussaini and Craig Luccarini and Joe Dennis and Sarah Jugurnauth-Little and Tokhir Dadaev and Neal, {David E} and Hamdy, {Freddie C} and Donovan, {Jenny L} and Ken Muir and Giles, {Graham G} and Gianluca Severi and Fredrik Wiklund and Henrik Gronberg and Haiman, {Christopher A} and Fredrick Schumacher and Henderson, {Brian E} and {Le Marchand}, Loic and Sara Lindstrom and Peter Kraft and Hunter, {David J} and Susan Gapstur and Chanock, {Stephen J} and Berndt, {Sonja I} and Demetrius Albanes and Gerald Andriole and Johanna Schleutker and Maren Weischer and Federico Canzian and Elio Riboli and Key, {Tim J} and Travis, {Ruth C} and Daniele Campa and Ingles, {Sue A} and John, {Esther M} and Hayes, {Richard B} and Pharoah, {Paul D P} and Nora Pashayan and Kay-Tee Khaw and Stanford, {Janet L} and Ostrander, {Elaine A} and Signorello, {Lisa B} and Thibodeau, {Stephen N} and Dan Schaid and Nordestgaard, {B{\o}rge G} and B{\o}rge Nordestgaard",

year = "2013",

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doi = "10.1038/ng.2560",

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T1 - Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

AU - Eeles, Rosalind A

AU - Olama, Ali Amin Al

AU - Benlloch, Sara

AU - Saunders, Edward J

AU - Leongamornlert, Daniel A

AU - Tymrakiewicz, Malgorzata

AU - Ghoussaini, Maya

AU - Luccarini, Craig

AU - Dennis, Joe

AU - Jugurnauth-Little, Sarah

AU - Dadaev, Tokhir

AU - Neal, David E

AU - Hamdy, Freddie C

AU - Donovan, Jenny L

AU - Muir, Ken

AU - Giles, Graham G

AU - Severi, Gianluca

AU - Wiklund, Fredrik

AU - Gronberg, Henrik

AU - Haiman, Christopher A

AU - Schumacher, Fredrick

AU - Henderson, Brian E

AU - Le Marchand, Loic

AU - Lindstrom, Sara

AU - Kraft, Peter

AU - Hunter, David J

AU - Gapstur, Susan

AU - Chanock, Stephen J

AU - Berndt, Sonja I

AU - Albanes, Demetrius

AU - Andriole, Gerald

AU - Schleutker, Johanna

AU - Weischer, Maren

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Tim J

AU - Travis, Ruth C

AU - Campa, Daniele

AU - Ingles, Sue A

AU - John, Esther M

AU - Hayes, Richard B

AU - Pharoah, Paul D P

AU - Pashayan, Nora

AU - Khaw, Kay-Tee

AU - Stanford, Janet L

AU - Ostrander, Elaine A

AU - Signorello, Lisa B

AU - Thibodeau, Stephen N

AU - Schaid, Dan

AU - Nordestgaard, Børge G

AU - The COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative

PY - 2013/4

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N2 - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

AB - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

U2 - 10.1038/ng.2560

DO - 10.1038/ng.2560

M3 - Journal article

C2 - 23535732

SN - 1061-4036

VL - 45

SP - 385

EP - 391

JO - Nature: New biology

JF - Nature: New biology

IS - 4

ER -

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

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