BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Hermela Shimelis; Romy L S Mesman; Catharina Von Nicolai; Asa Ehlen; Lucia Guidugli; Charlotte Martin; Fabienne M G R Calléja; Huong Meeks; Emily Hallberg; Jamie Hinton; Jenna Lilyquist; Chunling Hu; Cora M Aalfs; Kristiina Aittomäki; Irene Andrulis; Hoda Anton-Culver; Volker Arndt; Matthias W Beckmann; Javier Benitez; Natalia V Bogdanova; Stig E Bojesen; Manjeet K Bolla; Anne-Lise Borresen-Dale; Hiltrud Brauch; Paul Brennan; Hermann Brenner; Annegien Broeks; Barbara Brouwers; Thomas Brüning; Barbara Burwinkel; Jenny Chang-Claude; Georgia Chenevix-Trench; Ching-Yu Cheng; Ji-Yeob Choi; J Margriet Collée; Angela Cox; Simon S Cross; Kamila Czene; Hatef Darabi; Joe Dennis; Thilo Dörk; Isabel Dos-Santos-Silva; Alison M Dunning; Peter A Fasching; Jonine Figueroa; Henrik Flyger; Montserrat García-Closas; Graham G Giles; Gord Glendon; Pascal Guénel; Christopher A Haiman; Per Hall; Ute Hamann; Mikael Hartman; Frans B Hogervorst; Antoinette Hollestelle; John L Hopper; Hidemi Ito; Anna Jakubowska; Daehee Kang; Veli-Matti Kosma; Vessela Kristensen; Kah-Nyin Lai; Diether Lambrechts; Loic Le Marchand; Jingmei Li; Annika Lindblom; Artitaya Lophatananon; Jan Lubinski; Eva Machackova; Arto Mannermaa; Sara Margolin; Frederik Marme; Keitaro Matsuo; Hui Miao; Kyriaki Michailidou; Roger L Milne; Kenneth Muir; Susan L Neuhausen; Heli Nevanlinna; Janet E Olson; Curtis Olswold; Jan J C Oosterwijk; Ana Osorio; Paolo Peterlongo; Julian Peto; Paul D P Pharoah; Katri Pylkäs; Paolo Radice; Muhammad Usman Rashid; Valerie Rhenius; Anja Rudolph; Suleeporn Sangrajrang; Elinor J Sawyer; Marjanka K Schmidt; Minouk J Schoemaker; Caroline Seynaeve; Mitul Shah; Chen-Yang Shen; Martha Shrubsole; Xiao-Ou Shu; Susan Slager; Melissa C Southey; Daniel O Stram; Anthony Swerdlow; Soo H Teo; Ian Tomlinson; Diana Torres; Thérèse Truong; Christi J van Asperen; Lizet E van der Kolk; Qin Wang; Robert Winqvist; Anna H Wu; Jyh-Cherng Yu; Wei Zheng; Ying Zheng; Jennifer Leary; Logan Walker; Lenka Foretova; Florentia Fostira; Kathleen B M Claes; Liliana Varesco; Setareh Moghadasi; Douglas F Easton; Amanda Spurdle; Peter Devilee; Harry Vrieling; Alvaro N A Monteiro; David E Goldgar; Aura Carreira; Maaike P G Vreeswijk; Fergus J Couch

doi:10.1158/0008-5472.can-16-2568

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Hermela Shimelis, Romy L S Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne M G R Calléja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M Aalfs, Kristiina Aittomäki, Irene Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Javier Benitez, Natalia V BogdanovaStig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dörk, Isabel Dos-Santos-Silva, Alison M Dunning, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G Giles, Gord Glendon, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B Hogervorst, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L Milne, Kenneth Muir, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Curtis Olswold, Jan J C Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Katri Pylkäs, Paolo Radice, Muhammad Usman Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Minouk J Schoemaker, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Martha Shrubsole, Xiao-Ou Shu, Susan Slager, Melissa C Southey, Daniel O Stram, Anthony Swerdlow, Soo H Teo, Ian Tomlinson, Diana Torres, Thérèse Truong, Christi J van Asperen, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Anna H Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan Walker, Lenka Foretova, Florentia Fostira, Kathleen B M Claes, Liliana Varesco, Setareh Moghadasi, Douglas F Easton, Amanda Spurdle, Peter Devilee, Harry Vrieling, Alvaro N A Monteiro, David E Goldgar, Aura Carreira, Maaike P G Vreeswijk, Fergus J Couch

Institut for Klinisk Medicin

37 Citationer (Scopus)

Abstract

Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case-control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls). The BRCA2 c.9104A>C, p.Tyr3035Ser (OR = 2.52; P = 0.04), and BRCA1 c.5096G>A, p.Arg1699Gln (OR = 4.29; P = 0.009) variant were associated with moderately increased risks of breast cancer among Europeans, whereas BRCA2 c.7522G>A, p.Gly2508Ser (OR = 2.68; P = 0.004), and c.8187G>T, p.Lys2729Asn (OR = 1.4; P = 0.004) were associated with moderate and low risks of breast cancer among Asians. Functional characterization of the BRCA2 variants using four quantitative assays showed reduced BRCA2 activity for p.Tyr3035Ser compared with wild-type. Overall, our results show how BRCA2 missense variants that influence protein function can confer clinically relevant, moderately increased risks of breast cancer, with potential implications for risk management guidelines in women with these specific variants.

Originalsprog	Engelsk
Tidsskrift	Cancer Research
Vol/bind	77
Udgave nummer	11
Sider (fra-til)	2789-2799
ISSN	0008-5472
DOI	https://doi.org/10.1158/0008-5472.can-16-2568
Status	Udgivet - 1 jun. 2017

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10.1158/0008-5472.can-16-2568

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Shimelis, H., Mesman, R. L. S., Von Nicolai, C., Ehlen, A., Guidugli, L., Martin, C., Calléja, F. M. G. R., Meeks, H., Hallberg, E., Hinton, J., Lilyquist, J., Hu, C., Aalfs, C. M., Aittomäki, K., Andrulis, I., Anton-Culver, H., Arndt, V., Beckmann, M. W., Benitez, J., ... Couch, F. J. (2017). BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer. Cancer Research, 77(11), 2789-2799. https://doi.org/10.1158/0008-5472.can-16-2568

Shimelis, H, Mesman, RLS, Von Nicolai, C, Ehlen, A, Guidugli, L, Martin, C, Calléja, FMGR, Meeks, H, Hallberg, E, Hinton, J, Lilyquist, J, Hu, C, Aalfs, CM, Aittomäki, K, Andrulis, I, Anton-Culver, H, Arndt, V, Beckmann, MW, Benitez, J, Bogdanova, NV, Bojesen, SE, Bolla, MK, Borresen-Dale, A-L, Brauch, H, Brennan, P, Brenner, H, Broeks, A, Brouwers, B, Brüning, T, Burwinkel, B, Chang-Claude, J, Chenevix-Trench, G, Cheng, C-Y, Choi, J-Y, Collée, JM, Cox, A, Cross, SS, Czene, K, Darabi, H, Dennis, J, Dörk, T, Dos-Santos-Silva, I, Dunning, AM, Fasching, PA, Figueroa, J, Flyger, H, García-Closas, M, Giles, GG, Glendon, G, Guénel, P, Haiman, CA, Hall, P, Hamann, U, Hartman, M, Hogervorst, FB, Hollestelle, A, Hopper, JL, Ito, H, Jakubowska, A, Kang, D, Kosma, V-M, Kristensen, V, Lai, K-N, Lambrechts, D, Marchand, LL, Li, J, Lindblom, A, Lophatananon, A, Lubinski, J, Machackova, E, Mannermaa, A, Margolin, S, Marme, F, Matsuo, K, Miao, H, Michailidou, K, Milne, RL, Muir, K, Neuhausen, SL, Nevanlinna, H, Olson, JE, Olswold, C, Oosterwijk, JJC, Osorio, A, Peterlongo, P, Peto, J, Pharoah, PDP, Pylkäs, K, Radice, P, Rashid, MU, Rhenius, V, Rudolph, A, Sangrajrang, S, Sawyer, EJ, Schmidt, MK, Schoemaker, MJ, Seynaeve, C, Shah, M, Shen, C-Y, Shrubsole, M, Shu, X-O, Slager, S, Southey, MC, Stram, DO, Swerdlow, A, Teo, SH, Tomlinson, I, Torres, D, Truong, T, van Asperen, CJ, van der Kolk, LE, Wang, Q, Winqvist, R, Wu, AH, Yu, J-C, Zheng, W, Zheng, Y, Leary, J, Walker, L, Foretova, L, Fostira, F, Claes, KBM, Varesco, L, Moghadasi, S, Easton, DF, Spurdle, A, Devilee, P, Vrieling, H, Monteiro, ANA, Goldgar, DE, Carreira, A, Vreeswijk, MPG & Couch, FJ 2017, 'BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer', Cancer Research, bind 77, nr. 11, s. 2789-2799. https://doi.org/10.1158/0008-5472.can-16-2568

@article{1add3c6d79b5456ba3f2e5008901a661,

title = "BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer",

abstract = "Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case-control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls). The BRCA2 c.9104A>C, p.Tyr3035Ser (OR = 2.52; P = 0.04), and BRCA1 c.5096G>A, p.Arg1699Gln (OR = 4.29; P = 0.009) variant were associated with moderately increased risks of breast cancer among Europeans, whereas BRCA2 c.7522G>A, p.Gly2508Ser (OR = 2.68; P = 0.004), and c.8187G>T, p.Lys2729Asn (OR = 1.4; P = 0.004) were associated with moderate and low risks of breast cancer among Asians. Functional characterization of the BRCA2 variants using four quantitative assays showed reduced BRCA2 activity for p.Tyr3035Ser compared with wild-type. Overall, our results show how BRCA2 missense variants that influence protein function can confer clinically relevant, moderately increased risks of breast cancer, with potential implications for risk management guidelines in women with these specific variants.",

keywords = "Aged, Amino Acid Substitution, Animals, BRCA2 Protein, Breast Neoplasms, Case-Control Studies, Female, Genotype, Germ-Line Mutation, Humans, Mice, Mutation, Missense, Risk, Journal Article",

author = "Hermela Shimelis and Mesman, {Romy L S} and {Von Nicolai}, Catharina and Asa Ehlen and Lucia Guidugli and Charlotte Martin and Call{\'e}ja, {Fabienne M G R} and Huong Meeks and Emily Hallberg and Jamie Hinton and Jenna Lilyquist and Chunling Hu and Aalfs, {Cora M} and Kristiina Aittom{\"a}ki and Irene Andrulis and Hoda Anton-Culver and Volker Arndt and Beckmann, {Matthias W} and Javier Benitez and Bogdanova, {Natalia V} and Bojesen, {Stig E} and Bolla, {Manjeet K} and Anne-Lise Borresen-Dale and Hiltrud Brauch and Paul Brennan and Hermann Brenner and Annegien Broeks and Barbara Brouwers and Thomas Br{\"u}ning and Barbara Burwinkel and Jenny Chang-Claude and Georgia Chenevix-Trench and Ching-Yu Cheng and Ji-Yeob Choi and Coll{\'e}e, {J Margriet} and Angela Cox and Cross, {Simon S} and Kamila Czene and Hatef Darabi and Joe Dennis and Thilo D{\"o}rk and Isabel Dos-Santos-Silva and Dunning, {Alison M} and Fasching, {Peter A} and Jonine Figueroa and Henrik Flyger and Montserrat Garc{\'i}a-Closas and Giles, {Graham G} and Gord Glendon and Pascal Gu{\'e}nel and Haiman, {Christopher A} and Per Hall and Ute Hamann and Mikael Hartman and Hogervorst, {Frans B} and Antoinette Hollestelle and Hopper, {John L} and Hidemi Ito and Anna Jakubowska and Daehee Kang and Veli-Matti Kosma and Vessela Kristensen and Kah-Nyin Lai and Diether Lambrechts and Marchand, {Loic Le} and Jingmei Li and Annika Lindblom and Artitaya Lophatananon and Jan Lubinski and Eva Machackova and Arto Mannermaa and Sara Margolin and Frederik Marme and Keitaro Matsuo and Hui Miao and Kyriaki Michailidou and Milne, {Roger L} and Kenneth Muir and Neuhausen, {Susan L} and Heli Nevanlinna and Olson, {Janet E} and Curtis Olswold and Oosterwijk, {Jan J C} and Ana Osorio and Paolo Peterlongo and Julian Peto and Pharoah, {Paul D P} and Katri Pylk{\"a}s and Paolo Radice and Rashid, {Muhammad Usman} and Valerie Rhenius and Anja Rudolph and Suleeporn Sangrajrang and Sawyer, {Elinor J} and Schmidt, {Marjanka K} and Schoemaker, {Minouk J} and Caroline Seynaeve and Mitul Shah and Chen-Yang Shen and Martha Shrubsole and Xiao-Ou Shu and Susan Slager and Southey, {Melissa C} and Stram, {Daniel O} and Anthony Swerdlow and Teo, {Soo H} and Ian Tomlinson and Diana Torres and Th{\'e}r{\`e}se Truong and {van Asperen}, {Christi J} and {van der Kolk}, {Lizet E} and Qin Wang and Robert Winqvist and Wu, {Anna H} and Jyh-Cherng Yu and Wei Zheng and Ying Zheng and Jennifer Leary and Logan Walker and Lenka Foretova and Florentia Fostira and Claes, {Kathleen B M} and Liliana Varesco and Setareh Moghadasi and Easton, {Douglas F} and Amanda Spurdle and Peter Devilee and Harry Vrieling and Monteiro, {Alvaro N A} and Goldgar, {David E} and Aura Carreira and Vreeswijk, {Maaike P G} and Couch, {Fergus J}",

note = "{\textcopyright}2017 American Association for Cancer Research.",

year = "2017",

month = jun,

day = "1",

doi = "10.1158/0008-5472.can-16-2568",

language = "English",

volume = "77",

pages = "2789--2799",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research",

number = "11",

}

TY - JOUR

T1 - BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

AU - Shimelis, Hermela

AU - Mesman, Romy L S

AU - Von Nicolai, Catharina

AU - Ehlen, Asa

AU - Guidugli, Lucia

AU - Martin, Charlotte

AU - Calléja, Fabienne M G R

AU - Meeks, Huong

AU - Hallberg, Emily

AU - Hinton, Jamie

AU - Lilyquist, Jenna

AU - Hu, Chunling

AU - Aalfs, Cora M

AU - Aittomäki, Kristiina

AU - Andrulis, Irene

AU - Anton-Culver, Hoda

AU - Arndt, Volker

AU - Beckmann, Matthias W

AU - Benitez, Javier

AU - Bogdanova, Natalia V

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Borresen-Dale, Anne-Lise

AU - Brauch, Hiltrud

AU - Brennan, Paul

AU - Brenner, Hermann

AU - Broeks, Annegien

AU - Brouwers, Barbara

AU - Brüning, Thomas

AU - Burwinkel, Barbara

AU - Chang-Claude, Jenny

AU - Chenevix-Trench, Georgia

AU - Cheng, Ching-Yu

AU - Choi, Ji-Yeob

AU - Collée, J Margriet

AU - Cox, Angela

AU - Cross, Simon S

AU - Czene, Kamila

AU - Darabi, Hatef

AU - Dennis, Joe

AU - Dörk, Thilo

AU - Dos-Santos-Silva, Isabel

AU - Dunning, Alison M

AU - Fasching, Peter A

AU - Figueroa, Jonine

AU - Flyger, Henrik

AU - García-Closas, Montserrat

AU - Giles, Graham G

AU - Glendon, Gord

AU - Guénel, Pascal

AU - Haiman, Christopher A

AU - Hall, Per

AU - Hamann, Ute

AU - Hartman, Mikael

AU - Hogervorst, Frans B

AU - Hollestelle, Antoinette

AU - Hopper, John L

AU - Ito, Hidemi

AU - Jakubowska, Anna

AU - Kang, Daehee

AU - Kosma, Veli-Matti

AU - Kristensen, Vessela

AU - Lai, Kah-Nyin

AU - Lambrechts, Diether

AU - Marchand, Loic Le

AU - Li, Jingmei

AU - Lindblom, Annika

AU - Lophatananon, Artitaya

AU - Lubinski, Jan

AU - Machackova, Eva

AU - Mannermaa, Arto

AU - Margolin, Sara

AU - Marme, Frederik

AU - Matsuo, Keitaro

AU - Miao, Hui

AU - Michailidou, Kyriaki

AU - Milne, Roger L

AU - Muir, Kenneth

AU - Neuhausen, Susan L

AU - Nevanlinna, Heli

AU - Olson, Janet E

AU - Olswold, Curtis

AU - Oosterwijk, Jan J C

AU - Osorio, Ana

AU - Peterlongo, Paolo

AU - Peto, Julian

AU - Pharoah, Paul D P

AU - Pylkäs, Katri

AU - Radice, Paolo

AU - Rashid, Muhammad Usman

AU - Rhenius, Valerie

AU - Rudolph, Anja

AU - Sangrajrang, Suleeporn

AU - Sawyer, Elinor J

AU - Schmidt, Marjanka K

AU - Schoemaker, Minouk J

AU - Seynaeve, Caroline

AU - Shah, Mitul

AU - Shen, Chen-Yang

AU - Shrubsole, Martha

AU - Shu, Xiao-Ou

AU - Slager, Susan

AU - Southey, Melissa C

AU - Stram, Daniel O

AU - Swerdlow, Anthony

AU - Teo, Soo H

AU - Tomlinson, Ian

AU - Torres, Diana

AU - Truong, Thérèse

AU - van Asperen, Christi J

AU - van der Kolk, Lizet E

AU - Wang, Qin

AU - Winqvist, Robert

AU - Wu, Anna H

AU - Yu, Jyh-Cherng

AU - Zheng, Wei

AU - Zheng, Ying

AU - Leary, Jennifer

AU - Walker, Logan

AU - Foretova, Lenka

AU - Fostira, Florentia

AU - Claes, Kathleen B M

AU - Varesco, Liliana

AU - Moghadasi, Setareh

AU - Easton, Douglas F

AU - Spurdle, Amanda

AU - Devilee, Peter

AU - Vrieling, Harry

AU - Monteiro, Alvaro N A

AU - Goldgar, David E

AU - Carreira, Aura

AU - Vreeswijk, Maaike P G

AU - Couch, Fergus J

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case-control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls). The BRCA2 c.9104A>C, p.Tyr3035Ser (OR = 2.52; P = 0.04), and BRCA1 c.5096G>A, p.Arg1699Gln (OR = 4.29; P = 0.009) variant were associated with moderately increased risks of breast cancer among Europeans, whereas BRCA2 c.7522G>A, p.Gly2508Ser (OR = 2.68; P = 0.004), and c.8187G>T, p.Lys2729Asn (OR = 1.4; P = 0.004) were associated with moderate and low risks of breast cancer among Asians. Functional characterization of the BRCA2 variants using four quantitative assays showed reduced BRCA2 activity for p.Tyr3035Ser compared with wild-type. Overall, our results show how BRCA2 missense variants that influence protein function can confer clinically relevant, moderately increased risks of breast cancer, with potential implications for risk management guidelines in women with these specific variants.

AB - Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case-control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls). The BRCA2 c.9104A>C, p.Tyr3035Ser (OR = 2.52; P = 0.04), and BRCA1 c.5096G>A, p.Arg1699Gln (OR = 4.29; P = 0.009) variant were associated with moderately increased risks of breast cancer among Europeans, whereas BRCA2 c.7522G>A, p.Gly2508Ser (OR = 2.68; P = 0.004), and c.8187G>T, p.Lys2729Asn (OR = 1.4; P = 0.004) were associated with moderate and low risks of breast cancer among Asians. Functional characterization of the BRCA2 variants using four quantitative assays showed reduced BRCA2 activity for p.Tyr3035Ser compared with wild-type. Overall, our results show how BRCA2 missense variants that influence protein function can confer clinically relevant, moderately increased risks of breast cancer, with potential implications for risk management guidelines in women with these specific variants.

KW - Aged

KW - Amino Acid Substitution

KW - Animals

KW - BRCA2 Protein

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Female

KW - Genotype

KW - Germ-Line Mutation

KW - Humans

KW - Mice

KW - Mutation, Missense

KW - Risk

KW - Journal Article

U2 - 10.1158/0008-5472.can-16-2568

DO - 10.1158/0008-5472.can-16-2568

M3 - Journal article

C2 - 28283652

SN - 0008-5472

VL - 77

SP - 2789

EP - 2799

JO - Cancer Research

JF - Cancer Research

IS - 11

ER -

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

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