Iatrogenic displacement of tumor cells to the sentinel node after surgical excision in primary breast cancer

TY - JOUR

T1 - Iatrogenic displacement of tumor cells to the sentinel node after surgical excision in primary breast cancer

AU - Tvedskov, Tove F

AU - Jensen, Maj-Britt

AU - Kroman, Niels

AU - Balslev, Eva

PY - 2012/1

Y1 - 2012/1

N2 - Isolated tumor cells (ITC) are more common in the sentinel node (SN) after needle biopsy of a breast cancer, indicating iatrogenic displacement of tumor cells. We here investigate whether similar iatrogenic displacement occurs after surgical excision of a breast tumor. We compared the incidence of ITC in the SN of 414 breast cancer patients with recent surgical excision to a group of 16,960 patients without recent surgical procedure in a multivariate analysis by linking data from the Danish Breast Cancer Cooperative Group database and the Danish National Health Register. Moreover, the incidence of spread to non-SNs in patients with ITC in the SN after recent surgical excision was analyzed. We found an adjusted odds ratio on 3.73 (95% CI 2.57-5.43; P 

AB - Isolated tumor cells (ITC) are more common in the sentinel node (SN) after needle biopsy of a breast cancer, indicating iatrogenic displacement of tumor cells. We here investigate whether similar iatrogenic displacement occurs after surgical excision of a breast tumor. We compared the incidence of ITC in the SN of 414 breast cancer patients with recent surgical excision to a group of 16,960 patients without recent surgical procedure in a multivariate analysis by linking data from the Danish Breast Cancer Cooperative Group database and the Danish National Health Register. Moreover, the incidence of spread to non-SNs in patients with ITC in the SN after recent surgical excision was analyzed. We found an adjusted odds ratio on 3.73 (95% CI 2.57-5.43; P 

U2 - 10.1007/s10549-011-1720-y

DO - 10.1007/s10549-011-1720-y

M3 - Journal article

C2 - 21850395

SN - 0167-6806

VL - 131

SP - 223

EP - 229

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 1

ER -