Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes

Grith Lærkholm Hansen; Pia Foli-Andersen; Siri Fredheim; Claus B. Juhl; Line Sofie Remvig; Martin Høyer Rose; Ivana Rosenzweig; Sándor Beniczky; Birthe Olsen; Kasper Pilgaard; Jesper Johannesen

doi:10.1177/1932296816634357

Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes

Grith Lærkholm Hansen, Pia Foli-Andersen, Siri Fredheim, Claus B. Juhl, Line Sofie Remvig, Martin Høyer Rose, Ivana Rosenzweig, Sándor Beniczky, Birthe Olsen, Kasper Pilgaard, Jesper Johannesen

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

BACKGROUND: The purpose of this study was to explore the possible difference in the electroencephalogram (EEG) pattern between euglycemia and hypoglycemia in children with type 1 diabetes (T1D) during daytime and during sleep. The aim is to develop a hypoglycemia alarm based on continuous EEG measurement and real-time signal processing.

METHOD: Eight T1D patients aged 6-12 years were included. A hyperinsulinemic hypoglycemic clamp was performed to induce hypoglycemia both during daytime and during sleep. Continuous EEG monitoring was performed. For each patient, quantitative EEG (qEEG) measures were calculated. A within-patient analysis was conducted comparing hypoglycemia versus euglycemia changes in the qEEG. The nonparametric Wilcoxon signed rank test was performed. A real-time analyzing algorithm developed for adults was applied.

RESULTS: The qEEG showed significant differences in specific bands comparing hypoglycemia to euglycemia both during daytime and during sleep. In daytime the EEG-based algorithm identified hypoglycemia in all children on average at a blood glucose (BG) level of 2.5 ± 0.5 mmol/l and 18.4 (ranging from 0 to 55) minutes prior to blood glucose nadir. During sleep the nighttime algorithm did not perform.

CONCLUSIONS: We found significant differences in the qEEG in euglycemia and hypoglycemia both during daytime and during sleep. The algorithm developed for adults detected hypoglycemia in all children during daytime. The algorithm had too many false alarms during the night because it was more sensitive to deep sleep EEG patterns than hypoglycemia-related EEG changes. An algorithm for nighttime EEG is needed for accurate detection of nocturnal hypoglycemic episodes in children. This study indicates that a hypoglycemia alarm may be developed using real-time continuous EEG monitoring.

Originalsprog	Engelsk
Tidsskrift	Journal of Diabetes Science and Technology
Vol/bind	10
Udgave nummer	6
Sider (fra-til)	1222-1229
Antal sider	8
ISSN	1932-2968
DOI	https://doi.org/10.1177/1932296816634357
Status	Udgivet - 1 nov. 2016

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title = "Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes",

abstract = "BACKGROUND: The purpose of this study was to explore the possible difference in the electroencephalogram (EEG) pattern between euglycemia and hypoglycemia in children with type 1 diabetes (T1D) during daytime and during sleep. The aim is to develop a hypoglycemia alarm based on continuous EEG measurement and real-time signal processing.METHOD: Eight T1D patients aged 6-12 years were included. A hyperinsulinemic hypoglycemic clamp was performed to induce hypoglycemia both during daytime and during sleep. Continuous EEG monitoring was performed. For each patient, quantitative EEG (qEEG) measures were calculated. A within-patient analysis was conducted comparing hypoglycemia versus euglycemia changes in the qEEG. The nonparametric Wilcoxon signed rank test was performed. A real-time analyzing algorithm developed for adults was applied.RESULTS: The qEEG showed significant differences in specific bands comparing hypoglycemia to euglycemia both during daytime and during sleep. In daytime the EEG-based algorithm identified hypoglycemia in all children on average at a blood glucose (BG) level of 2.5 ± 0.5 mmol/l and 18.4 (ranging from 0 to 55) minutes prior to blood glucose nadir. During sleep the nighttime algorithm did not perform.CONCLUSIONS: We found significant differences in the qEEG in euglycemia and hypoglycemia both during daytime and during sleep. The algorithm developed for adults detected hypoglycemia in all children during daytime. The algorithm had too many false alarms during the night because it was more sensitive to deep sleep EEG patterns than hypoglycemia-related EEG changes. An algorithm for nighttime EEG is needed for accurate detection of nocturnal hypoglycemic episodes in children. This study indicates that a hypoglycemia alarm may be developed using real-time continuous EEG monitoring.",

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author = "Hansen, {Grith L{\ae}rkholm} and Pia Foli-Andersen and Siri Fredheim and Juhl, {Claus B.} and Remvig, {Line Sofie} and Rose, {Martin H{\o}yer} and Ivana Rosenzweig and S{\'a}ndor Beniczky and Birthe Olsen and Kasper Pilgaard and Jesper Johannesen",

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T1 - Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes

AU - Hansen, Grith Lærkholm

AU - Foli-Andersen, Pia

AU - Fredheim, Siri

AU - Juhl, Claus B.

AU - Remvig, Line Sofie

AU - Rose, Martin Høyer

AU - Rosenzweig, Ivana

AU - Beniczky, Sándor

AU - Olsen, Birthe

AU - Pilgaard, Kasper

AU - Johannesen, Jesper

PY - 2016/11/1

Y1 - 2016/11/1

N2 - BACKGROUND: The purpose of this study was to explore the possible difference in the electroencephalogram (EEG) pattern between euglycemia and hypoglycemia in children with type 1 diabetes (T1D) during daytime and during sleep. The aim is to develop a hypoglycemia alarm based on continuous EEG measurement and real-time signal processing.METHOD: Eight T1D patients aged 6-12 years were included. A hyperinsulinemic hypoglycemic clamp was performed to induce hypoglycemia both during daytime and during sleep. Continuous EEG monitoring was performed. For each patient, quantitative EEG (qEEG) measures were calculated. A within-patient analysis was conducted comparing hypoglycemia versus euglycemia changes in the qEEG. The nonparametric Wilcoxon signed rank test was performed. A real-time analyzing algorithm developed for adults was applied.RESULTS: The qEEG showed significant differences in specific bands comparing hypoglycemia to euglycemia both during daytime and during sleep. In daytime the EEG-based algorithm identified hypoglycemia in all children on average at a blood glucose (BG) level of 2.5 ± 0.5 mmol/l and 18.4 (ranging from 0 to 55) minutes prior to blood glucose nadir. During sleep the nighttime algorithm did not perform.CONCLUSIONS: We found significant differences in the qEEG in euglycemia and hypoglycemia both during daytime and during sleep. The algorithm developed for adults detected hypoglycemia in all children during daytime. The algorithm had too many false alarms during the night because it was more sensitive to deep sleep EEG patterns than hypoglycemia-related EEG changes. An algorithm for nighttime EEG is needed for accurate detection of nocturnal hypoglycemic episodes in children. This study indicates that a hypoglycemia alarm may be developed using real-time continuous EEG monitoring.

AB - BACKGROUND: The purpose of this study was to explore the possible difference in the electroencephalogram (EEG) pattern between euglycemia and hypoglycemia in children with type 1 diabetes (T1D) during daytime and during sleep. The aim is to develop a hypoglycemia alarm based on continuous EEG measurement and real-time signal processing.METHOD: Eight T1D patients aged 6-12 years were included. A hyperinsulinemic hypoglycemic clamp was performed to induce hypoglycemia both during daytime and during sleep. Continuous EEG monitoring was performed. For each patient, quantitative EEG (qEEG) measures were calculated. A within-patient analysis was conducted comparing hypoglycemia versus euglycemia changes in the qEEG. The nonparametric Wilcoxon signed rank test was performed. A real-time analyzing algorithm developed for adults was applied.RESULTS: The qEEG showed significant differences in specific bands comparing hypoglycemia to euglycemia both during daytime and during sleep. In daytime the EEG-based algorithm identified hypoglycemia in all children on average at a blood glucose (BG) level of 2.5 ± 0.5 mmol/l and 18.4 (ranging from 0 to 55) minutes prior to blood glucose nadir. During sleep the nighttime algorithm did not perform.CONCLUSIONS: We found significant differences in the qEEG in euglycemia and hypoglycemia both during daytime and during sleep. The algorithm developed for adults detected hypoglycemia in all children during daytime. The algorithm had too many false alarms during the night because it was more sensitive to deep sleep EEG patterns than hypoglycemia-related EEG changes. An algorithm for nighttime EEG is needed for accurate detection of nocturnal hypoglycemic episodes in children. This study indicates that a hypoglycemia alarm may be developed using real-time continuous EEG monitoring.

KW - Journal Article

U2 - 10.1177/1932296816634357

DO - 10.1177/1932296816634357

M3 - Journal article

C2 - 26920641

SN - 1932-2968

VL - 10

SP - 1222

EP - 1229

JO - Journal of diabetes science and technology

JF - Journal of diabetes science and technology

IS - 6

ER -

Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes

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