TY - JOUR
T1 - Humoral and cell-mediated immune responses in DNA immunized mink challenged with wild-type canine distemper virus
AU - Nielsen, Line
AU - Søgaard, Mette
AU - Karlskov-Mortensen, Peter
AU - Jensen, Trine Hammer
AU - Jensen, Tove Johanne Dannemann
AU - Aasted, Bent
AU - Blixenkrone-Møller, Merete
PY - 2009
Y1 - 2009
N2 - The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of CDV creates a constant viral reservoir among wildlife animals. Our results demonstrated early humoral and cell-mediated immune responses (IFN-gamma) in DNA vaccinated mink compared to mock-vaccinated mink after challenge with a Danish wild-type CDV. The DNA vaccine-induced immunity protected the natural host against disease development.
AB - The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of CDV creates a constant viral reservoir among wildlife animals. Our results demonstrated early humoral and cell-mediated immune responses (IFN-gamma) in DNA vaccinated mink compared to mock-vaccinated mink after challenge with a Danish wild-type CDV. The DNA vaccine-induced immunity protected the natural host against disease development.
KW - Former Faculty of Life Sciences
U2 - 10.1016/j.vaccine.2009.05.090
DO - 10.1016/j.vaccine.2009.05.090
M3 - Journal article
C2 - 19539579
SN - 0264-410X
VL - 27
SP - 4791
EP - 4797
JO - Vaccine
JF - Vaccine
IS - 35
ER -
