Human Transcriptome and Chromatin Modifications: An ENCODE Perspective

TY - JOUR

T1 - Human Transcriptome and Chromatin Modifications

T2 - An ENCODE Perspective

AU - Shen, Li

AU - Choi, Inchan

AU - Nestler, Eric J

AU - Won, Kyoung-Jae

PY - 2013/6

Y1 - 2013/6

N2 - A decade-long project, led by several international research groups, called the Encyclopedia of DNA Elements (ENCODE), recently released an unprecedented amount of data. The ambitious project covers transcriptome, cistrome, epigenome, and interactome data from more than 1,600 sets of experiments in human. To make use of this valuable resource, it is important to understand the information it represents and the techniques that were used to generate these data. In this review, we introduce the data that ENCODE generated, summarize the observations from the data analysis, and revisit a computational approach that ENCODE used to predict gene expression, with a focus on the human transcriptome and its association with chromatin modifications.

AB - A decade-long project, led by several international research groups, called the Encyclopedia of DNA Elements (ENCODE), recently released an unprecedented amount of data. The ambitious project covers transcriptome, cistrome, epigenome, and interactome data from more than 1,600 sets of experiments in human. To make use of this valuable resource, it is important to understand the information it represents and the techniques that were used to generate these data. In this review, we introduce the data that ENCODE generated, summarize the observations from the data analysis, and revisit a computational approach that ENCODE used to predict gene expression, with a focus on the human transcriptome and its association with chromatin modifications.

U2 - 10.5808/gi.2013.11.2.60

DO - 10.5808/gi.2013.11.2.60

M3 - Journal article

C2 - 23843771

SN - 1598-866X

VL - 11

SP - 60

EP - 67

JO - Genomics & informatics

JF - Genomics & informatics

IS - 2

ER -