@article{7ff4437074c711dbbee902004c4f4f50,
title = "Human immunodeficiency virus-associated malignant lymphoma in eastern Denmark diagnosed from 1990-1996: clinical features, histopathology, and association with Epstein-Barr virus and human herpesvirus-8",
abstract = "The clinicopathological features of human immunodeficiency virus (HIV)-associated lymphoma were investigated in a retrospective study of 85 adult patients in eastern Denmark diagnosed during the period 1990-1996. The possible pathogenetic role of Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) in these tumours was also studied. Seventy patients (82%) presented with extranodal disease and 26 (31%) had CNS involvement at diagnosis. Diffuse large cell B-cell lymphoma was the most frequent histological subtype, comprising 65 of 79 cases available for microscopic re-evaluation (82%) and including 20 of 23 evaluable patients with CNS lymphoma (87%). EBV RNA was demonstrated by in situ hybridization in 51 of 65 evaluable tumours (79%) and in 14 of 16 cases (88%) with CNS-lymphoma. Three cases showed a T-cell phenotype. The presence of HHV-8 DNA was analysed by PCR in 32 cases. A strong band consistent with tumour cell infection was detected in only one case, weaker bands being seen in 4 cases. None of these patients had primary effusion lymphomas. In conclusion, Danish AIDS-related lymphomas are of predominantly high-grade B-cell type with extranodal localization and atypical presentation. Our results provide further evidence that EBV plays a major role in the pathogenesis of large cell AIDS-related lymphoma, whereas HHV-8 does not appear to contribute significantly to the development of solid lymphomas in this group of patients.",
author = "Hansen, {P B} and M Penkowa and O Kirk and P Skinh{\o}j and C Pedersen and I Lisse and K Kiss and X Zhou and Hamilton-Dutoit, {S J}",
note = "Keywords: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; DNA, Viral; Denmark; Doxorubicin; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; In Situ Hybridization; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Polymerase Chain Reaction; Prednisone; RNA, Viral; Retrospective Studies; Treatment Outcome; Vincristine",
year = "2000",
language = "English",
volume = "64",
pages = "368--375",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell",
number = "6",
}