Human and equine cardiovascular endocrinology: beware to compare

TY - JOUR

T1 - Human and equine cardiovascular endocrinology

T2 - beware to compare

AU - Vekens, Nicky Van Der

AU - Hunter, Ingrid

AU - Gøtze, Jens Peter

AU - Decloedt, Annelies

AU - Clercq, Dominique De

AU - Loon, Gunther van

PY - 2013

Y1 - 2013

N2 - Cardiac biomarkers such as troponins and natriuretic peptides are routinely used in human medicine for the evaluation of myocardial damage and heart failure. Recently, these markers have also been introduced in veterinary medicine. Comparison between human and equine cardiac biomarker studies show important species differences, which can partly be explained by variations in physiology or pathophysiology. Most important are physiological differences in heart rate, cardiovascular response to exercise, food and water intake, and molecular elimination in plasma. Pathological differences are even more prominent. In humans, troponins and natriuretic peptides are mostly used for the diagnosis of acute coronary syndromes and heart failure. These cardiac entities, however, are rare in horses. In this species, cardiac biomarkers are rather proposed for the assessment of valvular or myocardial disease. In conclusion, these species differences corroborate that extrapolation of cardiac biomarker data should always be performed with caution and species-specific data should be applied whenever possible.

AB - Cardiac biomarkers such as troponins and natriuretic peptides are routinely used in human medicine for the evaluation of myocardial damage and heart failure. Recently, these markers have also been introduced in veterinary medicine. Comparison between human and equine cardiac biomarker studies show important species differences, which can partly be explained by variations in physiology or pathophysiology. Most important are physiological differences in heart rate, cardiovascular response to exercise, food and water intake, and molecular elimination in plasma. Pathological differences are even more prominent. In humans, troponins and natriuretic peptides are mostly used for the diagnosis of acute coronary syndromes and heart failure. These cardiac entities, however, are rare in horses. In this species, cardiac biomarkers are rather proposed for the assessment of valvular or myocardial disease. In conclusion, these species differences corroborate that extrapolation of cardiac biomarker data should always be performed with caution and species-specific data should be applied whenever possible.

U2 - 10.1097/XCE.0000000000000009

DO - 10.1097/XCE.0000000000000009

M3 - Journal article

SN - 2162-6898

VL - 2

SP - 67

EP - 76

JO - Cardiovascular Endocrinology

JF - Cardiovascular Endocrinology

IS - 4

ER -