How histological features of basal cell carcinomas influence image quality in optical coherence tomography

M. Mogensen; G.B.E. Jemec; B.M. Nürnberg; L. Thrane; T.M. Jørgensen; P.E. Andersen

doi:10.1002/jbio.201100006

How histological features of basal cell carcinomas influence image quality in optical coherence tomography

M. Mogensen, G.B.E. Jemec, B.M. Nürnberg, L. Thrane, T.M. Jørgensen, P.E. Andersen

30 Citationer (Scopus)

Abstract

Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only blurred in OCT images. Inflammation was more pronounced in blurred OCT images, whereas solar elastosis dominated in easily identified lesions. Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters.

Originalsprog	Engelsk
Tidsskrift	Journal of Biophotonics
Vol/bind	4
Udgave nummer	7-8
Sider (fra-til)	544-551
Antal sider	8
ISSN	1864-063X
DOI	https://doi.org/10.1002/jbio.201100006
Status	Udgivet - 1 aug. 2011

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1002/jbio.201100006

Andre filer og links

Link to publication in Scopus

Citationsformater

@article{664ea02b7cd64131a294a4264b1ec4ee,

title = "How histological features of basal cell carcinomas influence image quality in optical coherence tomography",

abstract = "Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only blurred in OCT images. Inflammation was more pronounced in blurred OCT images, whereas solar elastosis dominated in easily identified lesions. Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters.",

author = "M. Mogensen and G.B.E. Jemec and B.M. N{\"u}rnberg and L. Thrane and T.M. J{\o}rgensen and P.E. Andersen",

year = "2011",

month = aug,

day = "1",

doi = "10.1002/jbio.201100006",

language = "English",

volume = "4",

pages = "544--551",

journal = "Journal of Biophotonics",

issn = "1864-063X",

publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",

number = "7-8",

}

TY - JOUR

T1 - How histological features of basal cell carcinomas influence image quality in optical coherence tomography

AU - Mogensen, M.

AU - Jemec, G.B.E.

AU - Nürnberg, B.M.

AU - Thrane, L.

AU - Jørgensen, T.M.

AU - Andersen, P.E.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only blurred in OCT images. Inflammation was more pronounced in blurred OCT images, whereas solar elastosis dominated in easily identified lesions. Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters.

AB - Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only blurred in OCT images. Inflammation was more pronounced in blurred OCT images, whereas solar elastosis dominated in easily identified lesions. Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters.

UR - http://www.scopus.com/inward/record.url?scp=79960623058&partnerID=8YFLogxK

U2 - 10.1002/jbio.201100006

DO - 10.1002/jbio.201100006

M3 - Journal article

C2 - 21595042

AN - SCOPUS:79960623058

SN - 1864-063X

VL - 4

SP - 544

EP - 551

JO - Journal of Biophotonics

JF - Journal of Biophotonics

IS - 7-8

ER -

How histological features of basal cell carcinomas influence image quality in optical coherence tomography

Abstract

FN’s Verdensmål

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater