Home Parenteral Nutrition in Adult Patients with Chronic Intestinal Failure: The Evolution over 4 Decades in a Tertiary Referral Center

Christopher Filtenborg Brandt; Mark Hvistendahl; Rahim M. Naimi; Siri Tribler; Michael Staun; Per Brøbech; Palle Bekker Jeppesen

doi:10.1177/0148607116655449

Home Parenteral Nutrition in Adult Patients with Chronic Intestinal Failure: The Evolution over 4 Decades in a Tertiary Referral Center

Christopher Filtenborg Brandt^*, Mark Hvistendahl, Rahim M. Naimi, Siri Tribler, Michael Staun, Per Brøbech, Palle Bekker Jeppesen

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

36 Citationer (Scopus)

Abstract

Background/Aims: In Denmark, the public healthcare system ensures patients with intestinal failure (IF) the same rights for a life-saving treatment as patients with other organ failures. This study reports the epidemiological data from the largest Danish IF center. As one of the pioneering centers in treating IF with home parenteral nutrition (HPN), this study documents the HPN evolution and describes the demographics and outcome in one of the world's largest single-center cohorts. Methods: We included patients with IF discharged with HPN from 1970-2010. Data were extracted according to European Society for Clinical Nutrition and Metabolism classifications from the Copenhagen IF database. Results: Over the decades, we observed an exponential increase in the number of HPN patients. The 508 patients with IF collectively received HPN for 1751 years. While receiving HPN, 211 patients with IF (42%) died. Only 24 deaths were HPN related: sepsis (n = 10), liver disease (n = 12), central venous thrombosis (n = 1), and a complicated catheter placement (n = 1). The HPN-related mortality was as low as 0.014 deaths/HPN year. In the first decade, HPN was mainly provided to younger, intestinally resected adult patients with IF with inflammatory bowel disease (IBD), but numerically, they were subsequently outnumbered by elderly patients with IF with cancer or complications from non-IBD, noncancer abdominal surgery. Despite these demographic changes, the HPN-related mortality has decreased in the past decade. Conclusion: Evolving from being a rare, experimental treatment in the 1970s, HPN at present is safe with a low treatment-related mortality in the experienced center, despite HPN being more widely used in a more elderly population.

Originalsprog	Engelsk
Tidsskrift	Journal of Parenteral and Enteral Nutrition
Vol/bind	41
Udgave nummer	7
Sider (fra-til)	1178-1187
Antal sider	10
ISSN	0148-6071
DOI	https://doi.org/10.1177/0148607116655449
Status	Udgivet - sep. 2017

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10.1177/0148607116655449

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Home Parenteral Nutrition in Adult Patients with Chronic Intestinal Failure : The Evolution over 4 Decades in a Tertiary Referral Center. / Brandt, Christopher Filtenborg; Hvistendahl, Mark; Naimi, Rahim M. et al.

I: Journal of Parenteral and Enteral Nutrition, Bind 41, Nr. 7, 09.2017, s. 1178-1187.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{7357b57ce3dc461783c2038623d6afc1,

title = "Home Parenteral Nutrition in Adult Patients with Chronic Intestinal Failure: The Evolution over 4 Decades in a Tertiary Referral Center",

abstract = "Background/Aims: In Denmark, the public healthcare system ensures patients with intestinal failure (IF) the same rights for a life-saving treatment as patients with other organ failures. This study reports the epidemiological data from the largest Danish IF center. As one of the pioneering centers in treating IF with home parenteral nutrition (HPN), this study documents the HPN evolution and describes the demographics and outcome in one of the world's largest single-center cohorts. Methods: We included patients with IF discharged with HPN from 1970-2010. Data were extracted according to European Society for Clinical Nutrition and Metabolism classifications from the Copenhagen IF database. Results: Over the decades, we observed an exponential increase in the number of HPN patients. The 508 patients with IF collectively received HPN for 1751 years. While receiving HPN, 211 patients with IF (42%) died. Only 24 deaths were HPN related: sepsis (n = 10), liver disease (n = 12), central venous thrombosis (n = 1), and a complicated catheter placement (n = 1). The HPN-related mortality was as low as 0.014 deaths/HPN year. In the first decade, HPN was mainly provided to younger, intestinally resected adult patients with IF with inflammatory bowel disease (IBD), but numerically, they were subsequently outnumbered by elderly patients with IF with cancer or complications from non-IBD, noncancer abdominal surgery. Despite these demographic changes, the HPN-related mortality has decreased in the past decade. Conclusion: Evolving from being a rare, experimental treatment in the 1970s, HPN at present is safe with a low treatment-related mortality in the experienced center, despite HPN being more widely used in a more elderly population.",

keywords = "clinical outcome, home parenteral nutrition, intestinal failure, life cycle, research and diseases, short bowel syndrome, survival, adult",

author = "Brandt, {Christopher Filtenborg} and Mark Hvistendahl and Naimi, {Rahim M.} and Siri Tribler and Michael Staun and Per Br{\o}bech and Jeppesen, {Palle Bekker}",

year = "2017",

month = sep,

doi = "10.1177/0148607116655449",

language = "English",

volume = "41",

pages = "1178--1187",

journal = "Journal of Parenteral and Enteral Nutrition",

issn = "0148-6071",

publisher = "SAGE Publications",

number = "7",

}

TY - JOUR

T1 - Home Parenteral Nutrition in Adult Patients with Chronic Intestinal Failure

T2 - The Evolution over 4 Decades in a Tertiary Referral Center

AU - Brandt, Christopher Filtenborg

AU - Hvistendahl, Mark

AU - Naimi, Rahim M.

AU - Tribler, Siri

AU - Staun, Michael

AU - Brøbech, Per

AU - Jeppesen, Palle Bekker

PY - 2017/9

Y1 - 2017/9

N2 - Background/Aims: In Denmark, the public healthcare system ensures patients with intestinal failure (IF) the same rights for a life-saving treatment as patients with other organ failures. This study reports the epidemiological data from the largest Danish IF center. As one of the pioneering centers in treating IF with home parenteral nutrition (HPN), this study documents the HPN evolution and describes the demographics and outcome in one of the world's largest single-center cohorts. Methods: We included patients with IF discharged with HPN from 1970-2010. Data were extracted according to European Society for Clinical Nutrition and Metabolism classifications from the Copenhagen IF database. Results: Over the decades, we observed an exponential increase in the number of HPN patients. The 508 patients with IF collectively received HPN for 1751 years. While receiving HPN, 211 patients with IF (42%) died. Only 24 deaths were HPN related: sepsis (n = 10), liver disease (n = 12), central venous thrombosis (n = 1), and a complicated catheter placement (n = 1). The HPN-related mortality was as low as 0.014 deaths/HPN year. In the first decade, HPN was mainly provided to younger, intestinally resected adult patients with IF with inflammatory bowel disease (IBD), but numerically, they were subsequently outnumbered by elderly patients with IF with cancer or complications from non-IBD, noncancer abdominal surgery. Despite these demographic changes, the HPN-related mortality has decreased in the past decade. Conclusion: Evolving from being a rare, experimental treatment in the 1970s, HPN at present is safe with a low treatment-related mortality in the experienced center, despite HPN being more widely used in a more elderly population.

AB - Background/Aims: In Denmark, the public healthcare system ensures patients with intestinal failure (IF) the same rights for a life-saving treatment as patients with other organ failures. This study reports the epidemiological data from the largest Danish IF center. As one of the pioneering centers in treating IF with home parenteral nutrition (HPN), this study documents the HPN evolution and describes the demographics and outcome in one of the world's largest single-center cohorts. Methods: We included patients with IF discharged with HPN from 1970-2010. Data were extracted according to European Society for Clinical Nutrition and Metabolism classifications from the Copenhagen IF database. Results: Over the decades, we observed an exponential increase in the number of HPN patients. The 508 patients with IF collectively received HPN for 1751 years. While receiving HPN, 211 patients with IF (42%) died. Only 24 deaths were HPN related: sepsis (n = 10), liver disease (n = 12), central venous thrombosis (n = 1), and a complicated catheter placement (n = 1). The HPN-related mortality was as low as 0.014 deaths/HPN year. In the first decade, HPN was mainly provided to younger, intestinally resected adult patients with IF with inflammatory bowel disease (IBD), but numerically, they were subsequently outnumbered by elderly patients with IF with cancer or complications from non-IBD, noncancer abdominal surgery. Despite these demographic changes, the HPN-related mortality has decreased in the past decade. Conclusion: Evolving from being a rare, experimental treatment in the 1970s, HPN at present is safe with a low treatment-related mortality in the experienced center, despite HPN being more widely used in a more elderly population.

KW - clinical outcome

KW - home parenteral nutrition

KW - intestinal failure

KW - life cycle

KW - research and diseases

KW - short bowel syndrome

KW - survival, adult

U2 - 10.1177/0148607116655449

DO - 10.1177/0148607116655449

M3 - Journal article

C2 - 27323776

AN - SCOPUS:85032873079

SN - 0148-6071

VL - 41

SP - 1178

EP - 1187

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

IS - 7

ER -

Home Parenteral Nutrition in Adult Patients with Chronic Intestinal Failure: The Evolution over 4 Decades in a Tertiary Referral Center

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