@article{3e63ecc099fb11dd86a6000ea68e967b,
title = "HNF1 alpha activates the aminopeptidase N promoter in intestinal (Caco-2) cells.",
abstract = "The importance of HNF1 binding proteins for intestinal aminopeptidase N expression was investigated using the Caco-2 cell-line. Aminopeptidase N promoter activity in Caco-2 cells depends on the HNF1 element (positions -85 to -58) and co-transfection with an HNF1 alpha expression vector demonstrates a direct activation of the promoter by HNF1 alpha through this element. Electrophoretic mobility shift assays using nuclear extracts from Caco-2 cells show the presence of high amounts of HNF1 binding proteins irrespective of their state of differentiation.",
author = "J{\o}rgen Olsen and Lotte Laustsen and J Troelsen",
note = "Keywords: Aminopeptidases; Animals; Antigens, CD13; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Hela Cells; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Intestinal Mucosa; Nuclear Proteins; Promoter Regions (Genetics); Protein Binding; Swine; Transcription Factors; Tumor Cells, Cultured",
year = "1994",
language = "English",
volume = "342",
pages = "325--8",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "3",
}