TY - JOUR
T1 - HLA-DP antigens in patients with chronic autoimmune thrombocytopenia (AITP)
AU - Mueller-Eckhardt, G
AU - Pawelec, G
AU - Haas, R
AU - Otto, C
AU - Kiefel, V
AU - Ødum, Niels
AU - Mueller-Eckhardt, C
N1 - Keywords: Adolescent; Adult; Aged; Autoimmune Diseases; Chronic Disease; Female; HLA-DP Antigens; Humans; Male; Middle Aged; Phenotype; Thrombocytopenia
PY - 1989
Y1 - 1989
N2 - AITP, a disease with well-defined autoimmune character, has been previously studied for a possible HLA association. However, no such association with antigens of the A, B, C or DR loci was found. As this does not exclude a possible association with HLA-DP antigens, we have investigated 36 patients with AITP for DP w1, w2, w3, w4 and w5 by primed lymphocyte typing using locally derived as well as the original DP reagents as used in the 9th International Histocompatibility Workshop. Comparison of antigen frequencies with those of 254 healthy controls revealed an increased frequency of DPw5 in the patient group which, however, was not statistically significant. Other discrepancies were not observed.
AB - AITP, a disease with well-defined autoimmune character, has been previously studied for a possible HLA association. However, no such association with antigens of the A, B, C or DR loci was found. As this does not exclude a possible association with HLA-DP antigens, we have investigated 36 patients with AITP for DP w1, w2, w3, w4 and w5 by primed lymphocyte typing using locally derived as well as the original DP reagents as used in the 9th International Histocompatibility Workshop. Comparison of antigen frequencies with those of 254 healthy controls revealed an increased frequency of DPw5 in the patient group which, however, was not statistically significant. Other discrepancies were not observed.
M3 - Journal article
C2 - 2609321
SN - 2059-2302
VL - 34
SP - 121
EP - 126
JO - HLA
JF - HLA
IS - 2
ER -