History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

Albina N Minlikeeva; Jo L Freudenheim; Kevin H Eng; Rikki A Cannioto; Grace Friel; J Brian Szender; Brahm Segal; Kunle Odunsi; Paul Mayor; Brenda Diergaarde; Emese Zsiros; Linda E Kelemen; Martin Köbel; Helen Steed; Anna deFazio; Susan J Jordan; Peter A Fasching; Matthias W Beckmann; Harvey A Risch; Mary Anne Rossing; Jennifer A Doherty; Jenny Chang-Claude; Marc T Goodman; Thilo Dörk; Robert Edwards; Francesmary Modugno; Roberta B Ness; Keitaro Matsuo; Mika Mizuno; Beth Y Karlan; Ellen L Goode; Susanne K Kjær; Estrid Høgdall; Joellen M Schildkraut; Kathryn L Terry; Daniel W Cramer; Elisa V Bandera; Lisa E Paddock; Lambertus A Kiemeney; Leon F A G Massuger; Rebecca Sutphen; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A Gayther; Susan J Ramus; Aleksandra Gentry-Maharaj; Celeste L Pearce; Anna H Wu; Allan Jensen; Ovarian Cancer Association Consortium

doi:10.1158/1055-9965.epi-17-0367

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

Albina N Minlikeeva, Jo L Freudenheim, Kevin H Eng, Rikki A Cannioto, Grace Friel, J Brian Szender, Brahm Segal, Kunle Odunsi, Paul Mayor, Brenda Diergaarde, Emese Zsiros, Linda E Kelemen, Martin Köbel, Helen Steed, Anna deFazio, Susan J Jordan, Peter A Fasching, Matthias W Beckmann, Harvey A Risch, Mary Anne RossingJennifer A Doherty, Jenny Chang-Claude, Marc T Goodman, Thilo Dörk, Robert Edwards, Francesmary Modugno, Roberta B Ness, Keitaro Matsuo, Mika Mizuno, Beth Y Karlan, Ellen L Goode, Susanne K Kjær, Estrid Høgdall, Joellen M Schildkraut, Kathryn L Terry, Daniel W Cramer, Elisa V Bandera, Lisa E Paddock, Lambertus A Kiemeney, Leon F A G Massuger, Rebecca Sutphen, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste L Pearce, Anna H Wu, Allan Jensen, Ovarian Cancer Association Consortium

Institut for Klinisk Medicin

6 Citationer (Scopus)

Abstract

Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients. Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes. Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced). Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival. Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis.

Originalsprog	Engelsk
Tidsskrift	Cancer Epidemiology, Biomarkers & Prevention
Vol/bind	26
Udgave nummer	9
Sider (fra-til)	1470-1473
ISSN	1055-9965
DOI	https://doi.org/10.1158/1055-9965.epi-17-0367
Status	Udgivet - 1 sep. 2017

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Minlikeeva, A. N., Freudenheim, J. L., Eng, K. H., Cannioto, R. A., Friel, G., Szender, J. B., Segal, B., Odunsi, K., Mayor, P., Diergaarde, B., Zsiros, E., Kelemen, L. E., Köbel, M., Steed, H., deFazio, A., Jordan, S. J., Fasching, P. A., Beckmann, M. W., Risch, H. A., ... Ovarian Cancer Association Consortium (2017). History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer Epidemiology, Biomarkers & Prevention, 26(9), 1470-1473. https://doi.org/10.1158/1055-9965.epi-17-0367

Minlikeeva, AN, Freudenheim, JL, Eng, KH, Cannioto, RA, Friel, G, Szender, JB, Segal, B, Odunsi, K, Mayor, P, Diergaarde, B, Zsiros, E, Kelemen, LE, Köbel, M, Steed, H, deFazio, A, Jordan, SJ, Fasching, PA, Beckmann, MW, Risch, HA, Rossing, MA, Doherty, JA, Chang-Claude, J, Goodman, MT, Dörk, T, Edwards, R, Modugno, F, Ness, RB, Matsuo, K, Mizuno, M, Karlan, BY, Goode, EL, Kjær, SK , Høgdall, E, Schildkraut, JM, Terry, KL, Cramer, DW, Bandera, EV, Paddock, LE, Kiemeney, LA, Massuger, LFAG, Sutphen, R, Anton-Culver, H, Ziogas, A, Menon, U, Gayther, SA, Ramus, SJ, Gentry-Maharaj, A, Pearce, CL, Wu, AH, Jensen, A & Ovarian Cancer Association Consortium 2017, 'History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium', Cancer Epidemiology, Biomarkers & Prevention, bind 26, nr. 9, s. 1470-1473. https://doi.org/10.1158/1055-9965.epi-17-0367

@article{8ce5b903e49e433fbf2b8cdb0b8217a4,

title = "History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium",

abstract = "Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients. Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes. Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced). Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival. Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis.",

author = "Minlikeeva, {Albina N} and Freudenheim, {Jo L} and Eng, {Kevin H} and Cannioto, {Rikki A} and Grace Friel and Szender, {J Brian} and Brahm Segal and Kunle Odunsi and Paul Mayor and Brenda Diergaarde and Emese Zsiros and Kelemen, {Linda E} and Martin K{\"o}bel and Helen Steed and Anna deFazio and Jordan, {Susan J} and Fasching, {Peter A} and Beckmann, {Matthias W} and Risch, {Harvey A} and Rossing, {Mary Anne} and Doherty, {Jennifer A} and Jenny Chang-Claude and Goodman, {Marc T} and Thilo D{\"o}rk and Robert Edwards and Francesmary Modugno and Ness, {Roberta B} and Keitaro Matsuo and Mika Mizuno and Karlan, {Beth Y} and Goode, {Ellen L} and Kj{\ae}r, {Susanne K} and Estrid H{\o}gdall and Schildkraut, {Joellen M} and Terry, {Kathryn L} and Cramer, {Daniel W} and Bandera, {Elisa V} and Paddock, {Lisa E} and Kiemeney, {Lambertus A} and Massuger, {Leon F A G} and Rebecca Sutphen and Hoda Anton-Culver and Argyrios Ziogas and Usha Menon and Gayther, {Simon A} and Ramus, {Susan J} and Aleksandra Gentry-Maharaj and Pearce, {Celeste L} and Wu, {Anna H} and Allan Jensen and {Ovarian Cancer Association Consortium}",

note = "{\textcopyright}2017 American Association for Cancer Research.",

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month = sep,

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doi = "10.1158/1055-9965.epi-17-0367",

language = "English",

volume = "26",

pages = "1470--1473",

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TY - JOUR

T1 - History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

AU - Minlikeeva, Albina N

AU - Freudenheim, Jo L

AU - Eng, Kevin H

AU - Cannioto, Rikki A

AU - Friel, Grace

AU - Szender, J Brian

AU - Segal, Brahm

AU - Odunsi, Kunle

AU - Mayor, Paul

AU - Diergaarde, Brenda

AU - Zsiros, Emese

AU - Kelemen, Linda E

AU - Köbel, Martin

AU - Steed, Helen

AU - deFazio, Anna

AU - Jordan, Susan J

AU - Fasching, Peter A

AU - Beckmann, Matthias W

AU - Risch, Harvey A

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A

AU - Chang-Claude, Jenny

AU - Goodman, Marc T

AU - Dörk, Thilo

AU - Edwards, Robert

AU - Modugno, Francesmary

AU - Ness, Roberta B

AU - Matsuo, Keitaro

AU - Mizuno, Mika

AU - Karlan, Beth Y

AU - Goode, Ellen L

AU - Kjær, Susanne K

AU - Høgdall, Estrid

AU - Schildkraut, Joellen M

AU - Terry, Kathryn L

AU - Cramer, Daniel W

AU - Bandera, Elisa V

AU - Paddock, Lisa E

AU - Kiemeney, Lambertus A

AU - Massuger, Leon F A G

AU - Sutphen, Rebecca

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Menon, Usha

AU - Gayther, Simon A

AU - Ramus, Susan J

AU - Gentry-Maharaj, Aleksandra

AU - Pearce, Celeste L

AU - Wu, Anna H

AU - Jensen, Allan

AU - Ovarian Cancer Association Consortium

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients. Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes. Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced). Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival. Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis.

AB - Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients. Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes. Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced). Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival. Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis.

U2 - 10.1158/1055-9965.epi-17-0367

DO - 10.1158/1055-9965.epi-17-0367

M3 - Journal article

C2 - 28864456

SN - 1055-9965

VL - 26

SP - 1470

EP - 1473

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 9

ER -

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

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