Highly effective SNP-based association mapping and management of recessive defects in livestock

Carole Charlier; Wouter Coppieters; Frédéric Rollin; Daniel Desmecht; Jørgen Steen Agerholm; Nadine Cambisano; Eloisa Carta; Sabrina Dardano; Marc Dive; Corinne Fasquelle; Jean-Claude Frennet; Roger Hanset; Xavier Hubin; Claus Bøttcher Jørgensen; Latifa Karim; Matthew Kent; Kirsten Harvey; Brian R. Pearce; Patricia Simon; Nico Tama; Haisheng Nie; Sébastien Vandeputte; Sigbjorn Lien; Maria Longeri; Merete Fredholm; Robert J. Harvey; Michel Georges

doi:10.1038/ng.96

Highly effective SNP-based association mapping and management of recessive defects in livestock

Carole Charlier, Wouter Coppieters, Frédéric Rollin, Daniel Desmecht, Jørgen Steen Agerholm, Nadine Cambisano, Eloisa Carta, Sabrina Dardano, Marc Dive, Corinne Fasquelle, Jean-Claude Frennet, Roger Hanset, Xavier Hubin, Claus Bøttcher Jørgensen, Latifa Karim, Matthew Kent, Kirsten Harvey, Brian R. Pearce, Patricia Simon, Nico TamaHaisheng Nie, Sébastien Vandeputte, Sigbjorn Lien, Maria Longeri, Merete Fredholm, Robert J. Harvey, Michel Georges

208 Citationer (Scopus)

Abstract

The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	40
Udgave nummer	4
Sider (fra-til)	449-454
Antal sider	6
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.96
Status	Udgivet - 2008

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10.1038/ng.96

Citationsformater

Charlier, C., Coppieters, W., Rollin, F., Desmecht, D., Agerholm, J. S., Cambisano, N., Carta, E., Dardano, S., Dive, M., Fasquelle, C., Frennet, J-C., Hanset, R., Hubin, X., Jørgensen, C. B., Karim, L., Kent, M., Harvey, K., Pearce, B. R., Simon, P., ... Georges, M. (2008). Highly effective SNP-based association mapping and management of recessive defects in livestock. Nature Genetics, 40(4), 449-454. https://doi.org/10.1038/ng.96

Charlier, C, Coppieters, W, Rollin, F, Desmecht, D, Agerholm, JS, Cambisano, N, Carta, E, Dardano, S, Dive, M, Fasquelle, C, Frennet, J-C, Hanset, R, Hubin, X, Jørgensen, CB, Karim, L, Kent, M, Harvey, K, Pearce, BR, Simon, P, Tama, N, Nie, H, Vandeputte, S, Lien, S, Longeri, M, Fredholm, M, Harvey, RJ & Georges, M 2008, 'Highly effective SNP-based association mapping and management of recessive defects in livestock', Nature Genetics, bind 40, nr. 4, s. 449-454. https://doi.org/10.1038/ng.96

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title = "Highly effective SNP-based association mapping and management of recessive defects in livestock",

abstract = "The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.",

author = "Carole Charlier and Wouter Coppieters and Fr{\'e}d{\'e}ric Rollin and Daniel Desmecht and Agerholm, {J{\o}rgen Steen} and Nadine Cambisano and Eloisa Carta and Sabrina Dardano and Marc Dive and Corinne Fasquelle and Jean-Claude Frennet and Roger Hanset and Xavier Hubin and J{\o}rgensen, {Claus B{\o}ttcher} and Latifa Karim and Matthew Kent and Kirsten Harvey and Pearce, {Brian R.} and Patricia Simon and Nico Tama and Haisheng Nie and S{\'e}bastien Vandeputte and Sigbjorn Lien and Maria Longeri and Merete Fredholm and Harvey, {Robert J.} and Michel Georges",

year = "2008",

doi = "10.1038/ng.96",

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volume = "40",

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T1 - Highly effective SNP-based association mapping and management of recessive defects in livestock

AU - Charlier, Carole

AU - Coppieters, Wouter

AU - Rollin, Frédéric

AU - Desmecht, Daniel

AU - Agerholm, Jørgen Steen

AU - Cambisano, Nadine

AU - Carta, Eloisa

AU - Dardano, Sabrina

AU - Dive, Marc

AU - Fasquelle, Corinne

AU - Frennet, Jean-Claude

AU - Hanset, Roger

AU - Hubin, Xavier

AU - Jørgensen, Claus Bøttcher

AU - Karim, Latifa

AU - Kent, Matthew

AU - Harvey, Kirsten

AU - Pearce, Brian R.

AU - Simon, Patricia

AU - Tama, Nico

AU - Nie, Haisheng

AU - Vandeputte, Sébastien

AU - Lien, Sigbjorn

AU - Longeri, Maria

AU - Fredholm, Merete

AU - Harvey, Robert J.

AU - Georges, Michel

PY - 2008

Y1 - 2008

N2 - The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.

AB - The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.

U2 - 10.1038/ng.96

DO - 10.1038/ng.96

M3 - Journal article

SN - 1061-4036

VL - 40

SP - 449

EP - 454

JO - Nature: New biology

JF - Nature: New biology

IS - 4

ER -

Highly effective SNP-based association mapping and management of recessive defects in livestock

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