High species variation within the repertoire of trace amine receptors

TY - GEN

T1 - High species variation within the repertoire of trace amine receptors

AU - Gloriam, David E.

AU - Bjarnadóttir, T K

AU - Schiöth, H B

AU - Fredriksson, R

PY - 2005/4

Y1 - 2005/4

N2 - Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.

AB - Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.

KW - Amino Acid Sequence

KW - Animals

KW - Genetic Variation

KW - Humans

KW - Molecular Sequence Data

KW - Multigene Family

KW - Phylogeny

KW - Receptors, G-Protein-Coupled

KW - Species Specificity

U2 - 10.1196/annals.1327.052

DO - 10.1196/annals.1327.052

M3 - Conference article

C2 - 15891052

SN - 0077-8923

JO - Annals of The Lyceum of Natural History of New York

JF - Annals of The Lyceum of Natural History of New York

ER -