High plasma levels of intact and cleaved soluble urokinase receptor reflect immune activation and are independent predictors of mortality in HIV-1-infected patients

Sisse Rye Ostrowski, Timo Piironen, Gunilla Høyer-Hansen, Jan Gerstoft, Bente Klarlund Pedersen, Henrik Ullum

50 Citationer (Scopus)

Abstract

High blood levels of soluble urokinase receptor (suPAR) measured by enzyme-linked immunoassay (ELISA) (bulk measurement of 3-domain and 2-domain suPAR [suPAR(I-III), suPAR(II-III)], and suPAR(I-III) ligand complexes) strongly predict mortality in HIV-1-infected patients. This study investigated plasma levels of suPAR(I-III), suPAR(II-III), and 1-domain suPAR [suPAR(I)] and their predictive value for survival in HIV patients.
OriginalsprogEngelsk
TidsskriftJ A I D S
Vol/bind39
Udgave nummer1
Sider (fra-til)23-31
Antal sider9
ISSN1525-4135
StatusUdgivet - 2005

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