TY - JOUR
T1 - High glucose impairs superoxide production from isolated blood neutrophils
AU - Perner, A
AU - Nielsen, S E
AU - Rask-Madsen, J
PY - 2003/4
Y1 - 2003/4
N2 - Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.
AB - Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.
U2 - http://dx.doi.org/10.1007/s00134-002-1628-4
DO - http://dx.doi.org/10.1007/s00134-002-1628-4
M3 - Journal article
SN - 0935-1701
VL - 29
SP - 642
EP - 645
JO - European Journal of Intensive Care Medicine
JF - European Journal of Intensive Care Medicine
IS - 4
ER -